Kinase inhibitors and method of treating cancer
AssigneeUniversity Health Network
InventorsPeter B. Sampson, Yong Liu, Sze-Wan Li, Bryan T. Forrest, Heinz W. Pauls, Louise G. Edwards, Miklos Feher, Narendra Kumar B. Patel, Radoslaw Laufer
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Abstract
The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
Claims10
A compound represented by the following structural formula:
- or a pharmaceutically acceptable salt thereof, wherein:
- Ra is —F, methoxy, methyl or ethyl;
- R4 is —H, methyl, ethyl, 2-methoxyethyl or —CH2CONH2;
- and
- R6 is —C═C-(optionally substituted phenyl).
A compound represented by the following structural formula:
- or a pharmaceutically acceptable salt thereof.
A compound of represented by the following structural formula:
- or a pharmaceutically acceptable salt thereof.
A compound represented by the following structural formula:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.