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US 8,263,587 B2Granted
Benzoxazepine compounds, their preparation and use
AssigneePiramal Healthcare Limited
InventorsSwati Bal-Tembe, Bansi Lal, Satish Namdeo Sawant, Anagha Suhas Kulkarni
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Abstract
The invention provides a novel benzoxazepine compound of the general formula (I): wherein R1 and R2 are as defined in the specification; or a stereoisomer, a geometric isomer, a pharmaceutically acceptable salt, a pharmaceutically acceptable solvate, or a polymorph thereof; a process for its preparation; and a pharmaceutical composition including an effective amount of the compound. The compounds are useful in the treatment of insulin resistance and clinical conditions associated therewith.
Claims18
A compound of formula (I),
- wherein:
- -------- (dotted line) represents an optional bond;
- R1 is:
- where:
- R3 and R4 are, independently of each other:
- hydrogen;
- hydroxyl;
- alkoxy;
- C1-C4 alkyl;
- amino;
- or aryl;
- R5, R6 and R7 are, independently of each other:
- hydrogen;
- C1-C4 alkyl;
- or aryl;
- n is 0, 1 or 2;
- and
- the arrows indicate the point of attachment of R1 group;
- R2 is:
- mono or bicyclic heteroaryl, containing one nitrogen and optionally another heteroatom selected from nitrogen, sulphur or oxygen;
- which may be unsubstituted or substituted with R8, wherein R8 is:
- hydrogen;
- hydroxyl;
- alkoxy;
- C1-C4 alkyl;
- halogen;
- amino;
- or aryl;
- and
- a stereoisomer, geometric isomer or pharmaceutically acceptable salt thereof.
27 more elements
Dependencies are inferred from the claim text.