Organic compounds

A compound of formula I

• or a pharmaceutically acceptable salt, wherein:
• R1 is hydrogen;
• R2 is amino;
• A is CR3;
• B is N;
• Ar′ is
• E is CH or N;
• R3 is hydrogen, C1-C6-alkyl, C1-C6-haloalkyl, C4-C8 carbocyclyl, a 5-8 membered heterocyclyl or a group —Y—Z, where said rings are optionally substituted by one or more substituents selected from List X;
• Y is a direct link, —O—(CH2)n— or —N(R4)—(CH2)o—;
• Z is phenyl or a 5-6 membered heteroaryl, where said rings are optionally substituted by one or more substituents selected from List X;
• R4 is hydrogen or C1-C6-alkyl;
• R5 is SO2NR7R8 or NR9SO2R10;
• R6 is hydrogen, halo, hydroxyl, cyano, C1-C3-alkyl, C1-C3-haloalkyl, C1-C3-alkoxy or C1-C3-haloalkoxy;
• or R5 and R6 together form a 5-6 membered heteroaryl or 5-8 membered heterocyclyl, where each ring is optionally substituted by one or more substituents selected from List X;
• R7, R9, R11, R13 and R15 are independently hydrogen or C1-C6-alkyl;
• R8, R10, R12, R14 and R16 are independently hydrogen, C1-C6-alkyl or —(CH2)p—R17, or R10 and R12 are additionally independently C1-C6-alkoxy, where said alkyl and alkoxy groups may be substituted by one to five halo or by hydroxyl, C1-C6-alkoxy, NR18R19 or CN;
• R17 is C6-C14-aryl, 5-10 membered heteroaryl, C4-C8 carbocyclyl, a 4-8 membered heterocyclyl, a C6-C14-aryl fused with a C4-C8 carbocyclyl or a 4-8 membered heterocyclyl, or a 5-10 membered heteroaryl fused with a C4-C8 carbocyclyl or a 4-8 membered heterocyclyl, where said rings are optionally substituted by one or more substituents selected from List X;
• or R7 and R8, R13 and R14 or R15 and R16 may form a 4-8 membered heterocyclyl containing at least one N ring atom, where said ring is optionally substituted by halo, hydroxyl, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy or C1-C6-haloalkoxy or cyano;
• R18 and R19 are independently hydrogen or C1-C6-alkyl;
• n is an integer from 0 to 2, o is an integer from 0 to 2 and p is an integer from 0 to 2;
• List X is represented by hydroxyl, cyano, nitro, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-alkoxy, C1-C6-alkenyloxy, C2-C6-alkynyloxy, —O—(C1-C4-alkylene)-R20, —O—(C2-C4-alkylene)-R21, halogen, C1-C6-alkylcarbonyl, carboxy, C1-C6-alkoxycarbonyl, amino, C1-C6-alkylamino, di-C1-C6-alkylamino, C1-C6-alkylaminocarbonyl, di-C1-C6-alkylaminocarbonyl, C1-C6-alkylcarbonylamino, C1-C6-alkylcarbonyl(C1-C6-alkyl)amino, C1-C6-alkylsulfonylamino, C1-C6-alkylsulfonyl(C1-C6-alkyl)amino, C1-C6-thioalkyl, C1-C6-alkylsulfinyl, C1-C6-alkylsulfonyl, aminosulfonyl, C1-C6-alkylaminosulfonyl, di-C1-C6-alkylaminosulfonyl, phenyl or 5-6 membered heteroaryl, where each of the afore-mentioned hydrocarbon groups may be optionally substituted by one or more halogen, hydroxyl, C1-C6-alkoxy, amino, C1-C6-alkylamino, di-C1-C6-alkylamino or cyano, and where said phenyl or heteroaryl group may be optionally substituted by one or more groups selected from hydroxyl, cyano, nitro, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkenyl, C1-C6-alkynyl, C1-C6-alkoxy, C1-C6-alkenyloxy, C1-C6-alkynyloxy, halogen, C1-C6-alkylcarbonyl, carboxy, C1-C6-alkoxycarbonyl, amino, C1-C6-alkylamino, di-C1-C6-alkylamino, C1-C6-alkylaminocarbonyl, di-C1-C6-alkylaminocarbonyl, C1-C6-alkylcarbonylamino, C1-C6-alkylcarbonyl(C1-C6-alkyl)amino, C1-C6-alkylsulfonylamino, C1-C6-alkylsulfonyl(C1-C6-alkyl)amino, C1-C6-thioalkyl, C1-C6-alkylsulfinyl, C1-C6-alkylsulfonyl, aminosulfonyl, C1-C6-alkylaminosulfonyl or di-C1-C6-alkylaminosulfonyl groups;
• R20 represents C2-C4-alkenyl, C2-C4-alkynyl, halogen, cyano, nitro, C1-C6-alkylcarbonyl, carboxy, C1-C6-alkoxycarbonyl, C1-C6-thioalkyl, C1-C6-alkylsulfinyl, C1-C6-alkylsulfonyl, aminosulfonyl, C1-C6-alkylaminosulfonyl, di-C1-C6-alkylaminosulfonyl, phenyl, a C-linked 5-6 membered heteroaryl group, a C4-C6 carbocyclic group or a C-linked 5-6 membered heterocyclyl group, where said phenyl or cyclic groups may be optionally substituted by one or more hydroxyl, cyano, nitro, C1-C6-alkyl, C1-C6-alkenyl, C1-C6-alkynyl, C1-C6-alkoxy, C1-C6-alkenyloxy, C1-C6-alkynyloxy, halogen, C1-C6-alkylcarbonyl, carboxy, C1-C6-alkoxycarbonyl, amino, C1-C6-alkylamino, di-C1-C6-alkylamino, C1-C6-alkylaminocarbonyl, di-C1-C6-alkylaminocarbonyl, C1-C6-alkylcarbonylamino, C1-C6-alkylcarbonyl(C1-C6-alkyl)amino, C1-C6-alkylsulfonylamino, C1-C6-alkylsulfonyl(C1-C6-alkyl)amino, C1-C6-thioalkyl, C1-C6-alkylsulfinyl, C1-C6-alkylsulfonyl, aminosulfonyl, C1-C6-alkylaminosulfonyl or di-C1-C6-alkylaminosulfonyl groups, where each of the afore-mentioned hydrocarbon groups may be optionally substituted by one or more halogen, hydroxyl, C1-C6-alkoxy, amino, C1-C6-alkylamino, di-C1-C6-alkylamino or cyano;
• and
• R21 represents hydroxyl, C1-C4-alkoxy, C2-C4-alkenyloxy, C2-C4-alkynyloxy, amino, C1-C6-alkylamino, di-C1-C6-alkylamino, C1-C6-alkylaminocarbonyl, di-C1-C6-alkylaminocarbonyl, C1-C6-alkylcarbonylamino, C1-C6-alkylcarbonyl(C1-C6-alkyl)amino, C1-C6-alkylsulfonylamino, C1-C6-alkylsulfonyl(C1-C6-alkyl)amino, an N-linked 5-6 membered heteroaryl group or an N-linked 5-6 membered heterocyclyl where said cyclic groups may be optionally substituted by one or more hydroxyl, nitro, C1-C6-alkyl, C1-C6-alkenyl, C1-C6-alkynyl, C1-C6-alkoxy, C1-C6-alkenyloxy, C1-C6-alkynyloxy, halogen, C1-C6-alkylcarbonyl, carboxy, C1-C6-alkoxycarbonyl, amino, C1-C6-alkylamino, di-C1-C6-alkylamino, C1-C6-alkylaminocarbonyl, di-C1-C6-alkylaminocarbonyl, C1-C6-alkylcarbonylamino, C1-C6-alkylcarbonyl(C1-C6-alkyl)amino, C1-C6-alkylsulfonylamino, C1-C6-alkylsulfonyl(C1-C6-alkyl)amino, C1-C6-thioalkyl, C1-C6-alkylsulfinyl, C1-C6-alkylsulfonyl, aminosulfonyl, C1-C6-alkylaminosulfonyl or di-C1-C6-alkylaminosulfonyl groups, where each of the afore-mentioned hydrocarbon groups may be optionally substituted by one or more halogen, hydroxyl, C1-C6-alkoxy, amino, C1-C6-alkylamino, di-C1-C6-alkylamino or cyano.