Imidazopyridines

A pharmaceutical composition comprising a therapeutically effective amount of a compound of formula I

• wherein
• A is N;
• R1 is hydrogen, lower-alkyl or fluoro-lower-alkyl;
• R2 is halogen, C(O)NR7R8 or C(O)OR9;
• R3 is hydrogen, NR10R11, lower-alkyl, lower-alkoxy, fluoro-lower-alkyl or fluoro-lower-alkoxy;
• R4 is hydrogen, lower-alkyl, fluoro-lower-alkyl, lower alkoxy or fluoro-lower-alkoxy;
• R5 is aryl or heteroaryl, each of which is optionally substituted by 1 to 3 substituents independently selected from the group consisting of halogen, lower-alkyl, lower-alkoxy, fluoro-lower-alkyl, fluoro-lower-alkoxy and hydroxy;
• R7 and R8 are each independently selected from the group consisting of hydrogen, lower-alkyl, lower-alkoxy-lower-alkyl, fluoro-lower-alkyl, cycloalkyl, cycloalkyl-lower-alkyl, NH2-lower-alkyl, N(H,lower-alkyl)-lower-alkyl, N(lower-alkyl2)-lower-alkyl, hydroxy-lower-alkyl, hydroxy-lower-alkoxy-lower-alkyl, NH2C(O)-lower-alkyl, N(H,lower-alkyl)C(O)-lower-alkyl, N(lower-alkyl2)C(O)-lower-alkyl, lower-alkoxy, hydroxy-lower-alkyl-oxetanyl-lower-alkyl, oxo-tetrahydrofuranyl, tetrahydrofuranyl-lower-alkyl, oxo-tetrahydrofuranyl-lower-alkyl, hydroxy-fluoro-lower-alkyl, tetrahydrofuranyl, aryl and heteroaryl, wherein each aryl or heteroaryl is optionally substituted by 1 to 3 substituents independently selected from the group consisting of halogen, lower-alkyl, lower-alkoxy, fluoro-lower-alkyl, fluoro-lower-alkoxy and hydroxy,
• or R7 and R8, together with the nitrogen atom to which they are attached, form a heterocyclyl selected from the group consisting of pyrrolidinyl, azetidinyl, morpholinyl, 5,6-dihydro-8-H-[1,2,4]triazolo[4,3-a]pyrazinyl, 3,4-dihydro-1H-pyrrolo[1,2-a]pyrazinyl, 2-oxa-6-aza-spiro[3.3]heptyl, 5,6-dihydro-8H-imidazo[1,2-a]pyrazinyl, [1,4]oxazepanyl, piperazinyl, thiomorpholinyl and 2-oxa-5-aza-bicyclo[2.2.1]heptyl, which heterocyclyl is optionally substituted by 1 to 3 substituents independently selected from the group consisting of halogen, lower-alkyl, lower-alkyl-C(O), lower-alkoxy-lower-alkyl, oxo, hydroxy, hydroxy-lower-alkyl, N(lower-alkyl2), NH2, N(H,lower-alkyl), fluoro-lower-alkyl, fluoro-lower-alkyl-C(O), lower-alkoxy and fluoro-lower-alkoxy;
• R9 is hydrogen, lower-alkyl, or fluoro-lower-alkyl;
• R10 and R11 are each independently hydrogen, lower-alkyl or fluoro-lower-alkyl,
• or R10 and R11, together with the nitrogen atom to which they are attached, form a heterocyclyl selected from the group consisting of piperidinyl, morpholinyl, pyrrolidinyl, azetidinyl and piperazinyl, which heterocyclyl is optionally substituted by 1 to 3 substituents independently selected from the group consisting of halogen, lower-alkyl, lower-alkoxy, fluoro-lower-alkyl and fluoro-lower-alkoxy;
• or a pharmaceutically acceptable salt or ester thereof and a pharmaceutically acceptable carrier.