Treating picornavirus infection by targeting MicroRNA miR-141
AssigneeNational Taiwan University
InventorsBing-Ching Ho, Sung-Liang Yu, Pan-Chyr Yang, Chun-Nan Lee
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Abstract
Treatment of picornavirus infection by inhibiting miR-141 activity. Also disclosed herein are a method for identify miR-141 inhibitory compounds and a method for identifying a target viral infection to be treated by anti-miR-141 therapy.
Claims13
A method of treating infection caused by an enterovirus, comprising:
- administering to a subject infected with an enterovirus an antisense oligonucleotide of human miR-141 in an amount effective to treat said infection in the subject, wherein the enterovirus is selected from the group consisting of enterovirus 71 (EV71), coxsackievirus B3 (CVB3) and poliovirus type 3 (PV3).
A method of reducing viral protein production, comprising
- administering to a subject infected with an enterovirus an antisense oligonucleotide of human miR-141 in an amount effective to reduce viral protein production in the subject, wherein the enterovirus is selected from the group consisting of enterovirus 71 (EV71), coxsackievirus B3 (CVB3) and poliovirus type 3 (PV3).
A method for inhibiting viral proliferation or reducing viral protein production in a cell infected with an enterovirus, comprising in vitro treating the cell with an effective amount of an antisense oligonucleotide of miR-141, wherein the enterovirus is selected from the group consisting of enterovirus 71 (EV71), coxsackievirus B3 (CVB3) and poliovirus type 3 (PV3).
Dependencies are inferred from the claim text.