Chromatography of metal complexes
AssigneeGalera Therapeutics, LLC
InventorsUrszula J. Slomczynska, Bobby N. Trawick, Dennis P. Riley, Arati Naik
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Abstract
A high performance liquid chromatography method to routinely and reproducibly detect and quantitate metal complexes is provided. The metal complexes used in the method of the invention can be different metal complexes, or they can be stereoisomers of the same metal complexes. The high performance liquid chromatography method of the present invention is suitable for the separation of diastereomers of the same metal complexes. Also provided is a chiral high performance liquid chromatography method to separate enantiomers of metal complexes. Superoxide dismutase mimetic compounds are also provided.
Claims11
A complex having the structure:
- wherein X is a coordinating anion selected from the group consisting of chloride anions, thiocyanate anions, stearate anions, acetate anions, trifluoroacetate anions, carboxylate anions, formate anions and azide anions.
A complex having the structure:
A complex having the structure:
A composition containing a single species of a MnII(1,4,7,10,13-pentaazacyclopentadecane) complex corresponding to the formula:
- wherein X is a coordinating anion selected from the group consisting of chloride anions, thiocyanate anions, stearate anions, acetate anions, trifluoroacetate anions, carboxylate anions, formate anions and azide anions.
Dependencies are inferred from the claim text.