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US 8,263,561 B2Granted
Composition and method for inhibiting, preventing, or ameliorating complications associated with ingestion of a medicinal, chemical, or biological substance or agent
AssigneeAmana Pharmaceuticals Corp.
InventorMohammed Saeed
Life of this patent
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Abstract
The present invention relates to a therapeutic composition comprising a pharmaceutically active agent and a diarrheagenic agent, wherein the diarrheagenic agent induces diarrhea to reduce the harmful or undesired side effects of the pharmaceutically active agent when the pharmaceutically active agent is ingested at a dose higher than the prescribed dose.
Claims11
A therapeutic composition comprising:
- a pharmaceutically active agent;
- and
- a diarrheagenic agent that is an enterotoxin comprising an amino acid sequence that is 95% identical to SEQ ID NO:
- 9;
- and
- wherein said diarrheagenic agent induces diarrhea to reduce the harmful or undesired side effects of the pharmaceutically active agent when the pharmaceutically active agent is ingested at a dose higher than the prescribed dose.
3 more elements
A therapeutic composition comprising:
- a pharmaceutically active agent;
- and
- a diarrheagenic agent;
- wherein the diarrheagenic agent is an enterotoxin comprising an amino acid sequence at least 95% identical to SEQ ID NO:
- 9;
- and said therapeutic composition comprises less than about 1 mg of the enterotoxin.
3 more elements
A method for reducing harmful or undesired side effects in a subject, caused by ingestion of a pharmaceutically active agent at a dose higher than the prescribed dosage comprising:
- administering to the subject a therapeutic composition comprising:
- a) a pharmaceutically active agent;
- and
- b) a diarrheagenic agent comprising an amino acid sequence at least 95% identical to SEQ ID NO:
- 9;
- wherein said diarrheagenic agent induces diarrhea to reduce the harmful or undesired side effects of the pharmaceutically active agent when the pharmaceutically active agent is ingested at a dose higher than the prescribed dose.
3 more elements
Dependencies are inferred from the claim text.