US 8,263,559 B2 · Feline granulocyte macrophage colony stimulating factor proteins

Abstract

The present invention relates to canine interleukin-4, canine or feline Flt-3 ligand, canine or feline CD40, canine or feline CD154, canine interleukin-5, canine interleukin-13, feline interferon alpha, and/or feline GM-CSF proteins; to canine interleukin-4, canine or feline Flt-3 ligand, canine or feline CD40, canine or feline CD154, canine interleukin-5, canine interleukin-13, feline interferon alpha, and/or feline GM-CSF nucleic acid molecules, including those that encode canine interleukin-4, canine or feline Flt-3 ligand, canine or feline CD40, canine or feline CD154, canine interleukin-5, canine interleukin-13, feline interferon alpha, and/or feline GM-CSF proteins, respectively; to antibodies raised against such proteins; and to inhibitory compounds that regulate such proteins. The present invention also includes methods to identify and obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to regulate an immune response in an animal.

Claims18

Dependent claims

An isolated protein comprising an amino acid sequence at least 95% identical to SEQ ID NO:125, wherein the protein comprises at least one amino acid selected from the group consisting of:

(a) an isoleucine at the position corresponding to position 19 of SEQ ID NO:125;
(b) an alanine at the position corresponding to position 39 of SEQ ID NO:125;
and
(c) an asparagine at the position corresponding to position 109 of SEQ ID NO:125;
wherein the isolated protein is able to stimulate the proliferation of granulocytes or macrophages.

2 more elements

An isolated protein encoded by a recombinant nucleic acid molecule comprising a nucleic acid sequence at least 95% identical to SEQ ID NO:124, wherein the nucleic acid sequence comprises at least one codon selected from the group consisting of:

(a) a codon encoding an isoleucine at the position corresponding to nucleotides 55-57 of SEQ ID NO:124;
(b) a codon encoding an alanine at the position corresponding to nucleotides 115-117 of SEQ ID NO:124;
and
(c) a codon encoding an asparagine at the position corresponding to nucleotides 325-327 of SEQ ID NO:124;
wherein the isolated protein is able to stimulate the proliferation of granulocytes or macrophages.

2 more elements

Dependencies are inferred from the claim text.

Feline granulocyte macrophage colony stimulating factor proteins

Life of this patent

Feline granulocyte macrophage colony stimulating factor proteins

Life of this patent

Abstract

Claims18