Exendin agonist compounds

A compound comprising the amino acid sequence of Formula (II):

• Xaa1 Xaa2 Xaa3 Gly Thr Xaa4 Xaa5 Xaa6 Xaa7 Xaa8 Ser
• Lys Gln Xaa9 Glu Glu Glu Ala Val Arg Leu Xaa10
• Xaa11 Xaa12 Xaa13 Leu X1 Gly Gly Xaa14 Ser Ser Gly
• Ala Xaa15 Xaa16 Xaa17 Xaa18-Z;
• wherein:
• Xaa1 4-imidazopropionyl;
• Xaa2 is Ser, Gly, Ala or Thr;
• Xaa3 is Asp or Glu;
• Xaa4 is Phe, Tyr or naphthylalanine;
• Xaa5 is Thr or Ser;
• Xaa6 is Ser or Thr;
• Xaa7 is Asp or Glu;
• Xaa8 is Leu, Ile, Val, pentylglycine or Met;
• Xaa9 is Leu, Ile, pentylglycine, Val or Met;
• Xaa10 is Phe, Tyr or naphthylalanine;
• Xaa11 is Ile, Val, Leu, pentylglycine, tert-butylglycine or Met;
• Xaa12 is Glu or Asp;
• Xaa13 is Trp, Phe, Tyr, or naphthylalanine;
• X1 is Lys Asn, Asn Lys, Lys-NHe-R Asn, or Asn Lys-NHe-R where R is Lys, Arg, C1-C10 straight chain or branched alkanoyl or cycloalkyanoyl;
• Xaa14, Xaa15, Xaa16 and Xaa17 are independently Pro, homoproline, 3Hyp, 4Hyp, thioproline, N-alkylglycine, N-alkylpentylglycine or N-alkylalanine;
• Xaa18 is Ser, Thr or Tyr;
• and
• Z is —OH or —NH2;
• with the proviso that the compound does not have the formula of SEQ ID. NO:1 or 2.