Sensors for detecting an analyte using silver nanoparticles
AssigneeThe Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin
InventorsMargaret Elizabeth Brennan, Gordon James Armstrong, John Kelly, Aine Marie Whelan
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Abstract
A sensor comprises silver nanoparticles in which substantially all of the surfaces of the silver nanoparticles are available for interaction with an analyte or for functionalization with a receptor which is capable of interacting with an analyte. Silver nanoparticles are preparated by forming the nanoparticles in the presence of a polymeric stabilizer such as PVA.
Claims46
A sensor for biosensing comprising discrete silver nanoparticles that are shaped and substantially plate-like in structure dispersed in an aqueous based system in which substantially all of the surfaces of the silver nanoparticles are available for interaction with an analyte or for functionalisation with a receptor which is capable of interacting with an analyte, wherein the silver nanoparticles provide a detectable change of from 1 to 150 nm in the position of their surface plasmon resonance in the UV-visible absorption spectrum in response to the binding of an analyte.
A method for preparing silver nanoparticles which comprises the step of forming the nanoparticles in the presence of a polymeric stabiliser.
A sensor for biosensing comprising discrete silver nanoparticles that are stable and that are shaped and substantially plate-like in structure dispersed in an aqueous based system in which substantially all of the surfaces of the silver nanoparticles are available for interaction with an analyte or for functionalisation with a receptor which is capable of interacting with an analyte, wherein the silver nanoparticles provide a detectable change of from 1 to 150 nm in the position of their surface plasmon resonance in the UV-visible absorption spectrum in response to the binding of an analyte.
Dependencies are inferred from the claim text.