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US 8,263,417 B2Granted
Self-illuminating dot systems and methods of use thereof
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsJianghong Rao, Min-kyung So, Chenjie Xu, Andreas M. Loening, Sanjiv S. Gambhir
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Abstract
Generally, conjugate systems, self-illuminating quantum dot conjugates, methods of detecting a target in a host, methods of treating a disease in a host, and the like, are described herein.
Claims18
A conjugate system, comprising:
- a self-illuminating quantum dot conjugate and a bioluminescence initiating compound, wherein the self-illuminating quantum dot conjugate includes a bioluminescence donor molecule and a quantum dot, wherein there is a covalent bond between the bioluminescence donor molecule and the quantum dot that directly bonds the bioluminescence donor molecule to the quantum dot, wherein the bioluminescence donor molecule and the bioluminescence initiating compound interact to produce a bioluminescence energy, and wherein the quantum dot emits a fluorescence energy in response to non-radiative transfer of the bioluminescence energy from the bioluminescence donor molecule to the quantum dot.
Dependencies are inferred from the claim text.