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US 8,263,398 B2Granted
Promoter and viral vector containing the same
OwnerJin-Hwang Liu, Chin-Cheng Liuinventors
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Abstract
The invention constructs an activating KRASmutant but not p53-responsive promoter and generates an E1B-55kD-deleted (ΔE1B-55kD) adenovirus, harboring a transcriptionally activating transgene and holding lytic replication ability in the tumor cells with activating KRASmutant. The adenovirus of the invention can be used in the treatment of cancers.
Claims7
An isolated nucleic acid promoter comprising the nucleic acid sequence as shown in SEQ ID NO:
- 2 (Δp53REP2 promoter).
Dependencies are inferred from the claim text.