US 8,263,378 B2 · Human β-adrenergic receptor kinase polypeptide and methods

Human β-adrenergic receptor kinase polypeptide and methods

AssigneeIncyte Corporation

InventorsVicki S. Elliott, Reena Khare, Thomas W. Richardson, Joseph P. Marquis, Anita Swarnakar, April J. A. Hafalia, Shanya D. Becha, Narinder K. Chawla-Walia, Mariah R. Baughn, Soo Yeun Lee, Uyen K. Tran, Henry Yue, Danniel B. Nguyen, Michael B. Thornton, Rajagopal Gururajan, Ameena R. Gandhi, Yan Lu, Monique G. Yao, Joana X. Li, Wen Luo, Ernestine A. Lee, Ian J. Forsythe, Craig H. Ison, Amy D. Wilson, Pei Jin

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Abstract

Various embodiments of the invention provide human kinases and phosphatases (KPP) polypeptides and polynucleotides which identify and encode KPP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of KPP.

Claims8

Dependent claims

An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:

Dependencies are inferred from the claim text.

Facts

Application

12/923,407Filed 20 Sep 2010 · division

Priority

30 Apr 2003

Published

US 2012/0014937 A119 Jan 2012

Granted

11 Sep 2012

Term ends

Not estimatedThe source records don’t support an estimate.

Classification13 codes

C12N 9/16
Hydrolases: acting on ester bonds
A61P 3/00
Drugs for disorders of the metabolism
A61P 9/00
Drugs for disorders of the cardiovascular system
A61P 25/00
Drugs for disorders of the nervous system

Family

Application60/467,491Us provisional application · filed 30 Apr 2003

Application60/469,441Us provisional application · filed 9 May 2003

Application60/476,408Us provisional application · filed 5 Jun 2003

Application60/494,656Us provisional application · filed 12 Aug 2003

Application60/524,415Us provisional application · filed 20 Nov 2003

Application60/528,750Us provisional application · filed 10 Dec 2003

PCT/US2004/009215Parent of this division · filed 24 Mar 2004

US 2012/0014937 A1Pre-grant publication · published 19 Jan 2012

Application10/554,917Parent of this division

US 7,829,682 B1Parent of this division

US 8,263,378 B2This patent

From the US filing history. Foreign family members aren’t listed.