AKT ligands and polynucleotides encoding AKT ligands
AssigneeIntrexon Corporation
InventorThomas D. Reed
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Abstract
The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate AKT activity. The ligands, homopolyligands, and heteropolyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands, homopolyligands, and heteropolyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands, homopolyligands, and heteropolyligands.
Claims15
A polynucleotide comprising a nucleotide sequence encoding a polypeptide comprising a structure X-S-Y, wherein X is a polypeptide monomer comprising an amino acid sequence at least 85% identical to SEQ ID NO:
- 74, wherein Y is a different polypeptide monomer comprising an amino acid sequence at least 85% identical to SEQ ID NO:
- 75, wherein S is an optional spacer molecule, and wherein the polypeptide inhibits AKT activity.
Dependencies are inferred from the claim text.