Method and kit for detection of autoimmune chronic urticaria
OwnerRonald Joseph Harbeck, Karen Mary Andrews +1inventors
InventorsRonald Joseph Harbeck, Karen Mary Andrews, Donald MacGlashan, Jr.
Life of this patent
Estimating the term…
Abstract
Disclosed is a rapid, non-invasive and highly specific and sensitive diagnostic assay for the identification of individuals with autoimmune chronic urticaria, which makes use of CD203c, and in some embodiments, additional proteins, as a marker for the disease. Test kits for diagnosis of an individual suspected of having autoimmune chronic urticaria are also disclosed. Also disclosed are a method of identifying compounds useful for treating autoimmune chronic urticaria and a method of treating autoimmune chronic urticaria.
Claims14
A kit for the diagnosis of autoimmune chronic urticaria, comprising:
- a) isolated donor cells that are selected for expressing CD203c and FcεRI and that upregulate the expression of CD203c upon stimulation of FcεRI, wherein the selected cells are present in a whole blood sample from a donor or are present in peripheral blood cells from a donor;
- b) a CD203c reagent that specifically binds to CD203c and detects for CD203c expression from the cells;
- and
- c) wherein the kit does not comprise interleukin-3 (IL-3).
Dependencies are inferred from the claim text.