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AssigneesMiyazaki Prefectural Industrial Support Foundation, Kagoshima University, Chugai Seiyaku Kabushiki Kaisha
InventorsHirohito Tsubouchi, Hirofumi Uto, Takeshi Okanoue, Yo-ichi Ishida, Yuko Sato, Masayuki Sudo
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Disclosed are: a marker for the diagnosis of a liver disease, which can determine the disease in a simple manner; an antibody directed against the marker; a diagnostic agent; a diagnosis method; and a method for marker detection in blood or serum. Proteome analysis revealed that quantities of the full-length kininogen and three partial peptides thereof (sequence A: position-440 to position-456, sequence B: position-439 to position-456, and sequence C: position-438 to position-456) in sera of patients with non-alcoholic fatty liver disease are significantly different from those in sera of healthy individuals; and a diagnostic agent and a detecting method for the non-alcoholic fatty liver disease that can be conveniently used for medical examination are established. The use of a combination of a kininogen-based marker and a C4-based marker (the full length sequence or partial peptides thereof) enables identification of chronic hepatitis and an asymptomatic virus carrier, as well as non-alcoholic fatty liver disease.
A detecting method for identification of a non-alcoholic fatty liver disease (NAFLD) in a subject, the method comprising detecting an increase in the serum level of at least one partial peptide selected from the group consisting of partial peptide A (SEQ ID NO:2), B (SEQ ID NO:3) and C (SEQ ID NO:4) in said subject relative to the serum level of such partial peptide in a healthy individual, said increase being indicative of NAFLD.
A detecting method for identification of a non-alcoholic fatty liver disease (NAFLD) in a subject which comprises
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