Methods for immobilizing anti-thrombogenic material onto a medical device or into a coating thereon
AssigneeAdvanced Cardiovascular Systems, Inc.
InventorsEugene T. Michal, Ni Ding, Christopher Buchko
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Abstract
The present invention is directed to a medical device having a polymerized base coat layer for the immobilization of an anti-thrombogenic material, such as heparin, thereon. The binding coat layer is comprised of various chemically functional groups which are stable and allow for the immobilization of the anti-thrombogenic material thereto. Methods for immobilizing the anti-thrombogenic material within the base coat layer posited on a surface of the medical device are also provided.
Claims12
A method for immobilizing an anti-thrombogenic material onto a coating deposited on a surface of an implantable medical device, the method comprising:
- preparing a base coat mixture for application to the surface of the medical device, the surface of the implantable medical device optionally coated with a primer layer;
- applying the base coat mixture to the surface of the medical device;
- polymerizing the base coat mixture to form a base coat layer on the medical device, the base coat layer comprising chemically functional groups;
- performing a reaction between the chemically functional groups of the base coat layer and excess amine-terminated material;
- rinsing the base coat layer with water;
- and
- performing a reaction between the anti-thrombogenic material and amine-terminated material on the surface of the medical device;
- wherein the amine-terminated material is amine-terminated hyaluronic acid or amine-terminated polyvinyl pyrrolidone.
Dependencies are inferred from the claim text.