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US 8,263,133 B2Granted
Multivalent clustering targeting strategy for drug carriers
AssigneeThe Regents of the University of California
InventorsTatiana Segura, Quinn Ng
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Abstract
The present invention provides clustered ligand vehicles for the delivery of a nucleic acid therapeutic agent to a target expressing a receptor. The invention further provides methods for treating a disease state by targeting a nucleic acid therapeutic agent to a target expressing a receptor using clustered ligand vehicles.
Claims14
A clustered ligand vehicle for delivery of a therapeutic agent to a target expressing a receptor, said vehicle comprising:
- one or more nanoparticles, each nanoparticle bearing a plurality of ligands, wherein said plurality of ligands comprises a combination of CAP peptides, wherein said CAP peptide are peptides that comprise the amino acid sequence Cys-Cys-Val-Val-Val-Thr (Seq ID NO:1):
- and CAP-RGD peptides, wherein said CAP-RGD peptides are peptides that comprise the amino acid sequence Cys-Cys-Val-Val-Val-Thr-Arg-Gly-Asp (SEQ ID NO:2);
- and
- a carrier comprising said therapeutic agent, wherein each of the one or more nanoparticles is conjugated to the surface of the carrier.
1 more element
Dependencies are inferred from the claim text.