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US 8,263,128 B2Granted
Solid pharmaceutical dispersions with enhanced bioavailability
AssigneeBend Research, Inc.
InventorsWilliam J. Curatolo, Scott M. Herbig, James A. S. Nightingale
Life of this patent
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Abstract
Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose acetate succinate (HPMCAS) provide increased aqueous solubility and/or biavailability in a use environment.
Claims23
A spray dried solid dispersion consisting of a sparingly water-soluble drug and hydroxypropyl methylcellulose acetate succinate (HPMCAS), said drug being molecularly dispersed and amorphous in said dispersion, having a drug:polymer weight ratio between 1:0.4 and 1:20, and said dispersion is a homogeneous solid solution of said drug in said HPMCAS.
Dependencies are inferred from the claim text.