Anthistamine-decongestant pharmaceutical compositions
AssigneeDr. Reddy's Laboratories, Inc.
InventorsKamalakar Talasila, Debashis Dash, Srinivas Irukula, Dhanorkar Vipin Tatyasaheb, Mailatur Sivaraman Mohan
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Abstract
The present invention relates to pharmaceutical compositions of antihistamine-decongestant combination. Specifically the invention relates to bilayered tablet formulation comprising antihistaminic decongestant combination. More specifically present invention relates to the novel polymorph of fexofenadine or pharmaceutically accepted salts thereof, with at least one decongestant in the form of bilayered tablet. The preferred polymorphs are polymorph A and polymorph X of fexofenadine hydrochloride.
Claims20
A pharmaceutical composition comprising:
- a) a tablet layer comprising an antihistaminic drug, a cellulose derivative, a polyol, a starch derivative, and a disintegrant;
- and
- b) a tablet layer comprising a decongestant drug and a sustained release compound.
A pharmaceutical composition comprising:
- a) a tablet layer comprising an antihistaminic drug, cellulose, mannitol, starch, and croscarmellose sodium;
- and
- b) a tablet layer comprising a decongestant drug and a mixture of polyvinyl acetate and povidone.
A pharmaceutical composition comprising:
- a) a tablet layer comprising crystalline form X of fexofenadine hydrochloride, about 20 to about 45 percent by weight cellulose, about 10 to about 30 percent by weight mannitol, about 5 to about 25 percent by weight starch, and about 4 to about 15 percent by weight of a disintegrant;
- and
- b) a tablet layer comprising a salt of pseudoephedrine and about 40 to about 80 percent by weight of a mixture comprising about 80 percent polyvinyl acetate and about 19 percent povidone.
Dependencies are inferred from the claim text.