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US 8,263,107 B2Granted
Functionalized chemically inert polymers for coatings
AssigneeAdvanced Cardiovascular Systems, Inc.
InventorsStephen Dirk Pacetti, Syed Faiyaz Ahmed Hossainy
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Abstract
Provided herein are methods for functionalizing a polymer for forming a coating and coatings and devices formed thereof or for functionalizing a coating or device surface including an polymer.
Claims8
A method of forming a coating on an implantable device, comprising
- (a) subjecting a polymer to ozonation to form a peroxy grafted polymer,
- (b) subjecting the peroxy grafted polymer to a process of reduction or CO2+H2O plasma treatment followed by immersion into an organic acid solution to generate a functionalized polymer,
- (c) attaching a biofunctional compound to the functionalized polymer, and
- (d) forming a coating on the implantable device comprising the polymer prior to ozonation or forming a coating on the implantable device comprising the functionalized polymer with the biofunctional compound attached thereon,
- wherein the organic acid is selected from the group consisting of maleic acid, fumaric acid, cinimanic acid, and a combination thereof,
- wherein the biofunctional compound is an RGD peptide, YIGSR peptide, ANP peptide, elastin, an endothelial progenitor cell (EPC) capturing antibody, an endothelial cell adhesion molecule (ECAM), or combinations thereof.
3 more elements
Dependencies are inferred from the claim text.