Gold-coated stent, oligonucleotide bound gold-coated stent, and process for producing the same

A preparation method of gold-plated stent of Structural Formula I-2 comprising the steps of:

• 1) reacting a gold-plated stent in Structural Formula IV, which is
• With 2-aminoalkanethiol in Chemical Formula 1, which is
• to form a stent of Structural Formula V, which is
• 2) reacting Structural Formula V with epihalogenhydrin in Chemical Formula 2, which is
• to form a stent of Structural Formula I-1, which is
• and
• 3) reacting Structural Formula I-1 with a diamine compound in Chemical Formula 3, which is
• to form the stent of Structural Formula I-2, which is
• wherein
• in the above structural formulas and chemical formulas, A is alkylene of C1-C30, which can be substituted with more than one heteroatom selected from oxygen, nitrogen, or sulfur;
• R2 is hydrogen or alkyl of C1-C30 substituted with more than one group selected from an amino group or alkyl amino group of C1-C30;
• X is Br or Cl;
• and
• m is an integer of 1 or more;
• n is an integer of 1 to 30;
• p is an integer of 1 to 30.

A preparation method of gold-plated stent comprising the steps of:

• 1) reacting a gold-plated stent in Structural Formula IV, which is
• with 2-aminoalkanethiol in Chemical Formula 1, which is
• to form a stent of Structural Formula V, which is
• 2) reacting the Structural Formula V with epihalogenhydrin in Chemical Formula 2, which is
• to form a stent of Structural Formula I-1, which is
• 3) reacting the Structural Formula I-1 with a diamine compound in Chemical Formula 3, which is
• to form a stent of Structural Formula I-2, which is
• and
• 4) binding an amine group (—NH— or —NH2) of the prepared stent in Structural Formula I-2 with oligonucleotide to form the gold-plated stent, wherein amine group (NH or NH2
• in the above structural formulas and chemical formulas, A is alkylene of C1-C30, which can be substituted with more than one heteroatom selected from oxygen, nitrogen, or sulfur;
• R2 is hydrogen or alkyl of C1-C30 substituted with more than one group selected from the amino group or alkyl amino group of C1-C30;
• X is Br or Cl;
• and
• m is an integer of 1 or more;
• n is an integer of 1 to 30;
• p is an integer of 1 to 30.

A preparation method of gold-plated stent of Structural Formula I-1 comprising the steps of:

• 1) reacting a gold-plated stent in Structural Formula IV, which is
• with 2-aminoalkanethiol in Chemical Formula 1, which is
• to form a stent of Structural Formula V, which is
• and
• 2) reacting the Structural Formula V with epihalogenhydrin in Chemical Formula 2, which is
• to form the stent of Structural Formula I-1, which is
• wherein;
• in the above structural formulas and chemical formulas, X is Br or Cl;
• m is an integer of 1 or more;
• n is an integer of 1 to 30.