Biomaterial drug delivery and surface modification compositions

A medical device coating comprising an emulsion comprising:

• an oil phase comprising a bioabsorbable terpolymer comprising from about 30 to about 50 weight percent of a polyoxyalkylene copolymer, from about 40 to about 50 weight percent epsilon-caprolactone, the balance of the copolymer comprising at least one other copolymerizable monomer selected from the group consisting of glycolide, lactide, p-dioxanone and trimethylene carbonate, in combination with a polymer comprising two or more monomers selected from the group consisting of lactide, glycolide, lactic-acid, lactones, glycolic acid, carbonates, orthoesters, absorbable urethanes, absorbable nylons, polyethylene glycol-polypropylene glycol, polystyrene, n-vinyl pyrrolidine, n-vinyl pyridine, C1-C12 acrylate monomer, C1-C12 methacrylate monomer, hydroxyethyl methacrylate, hydroxypropyl methacrylate, acrylic acid, potassium sulfopropyl acrylate, potassium sulfopropyl methacrylate, and 2-methacryloyl phosphorocholine, in combination with at least one organic solvent;
• at least one surfactant;
• and
• an aqueous phase comprising at least one antimicrobial component selected from the group consisting of lactoferrin, lactoferricin, defensins, cathelicidin, histatins, cecropins, magainin, and combinations thereof.