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US 8,263,103 B2Granted
Medical articles containing biodegradable polymers and acid-neutralizing cationic species
AssigneeBoston Scientific Scimed, Inc.
InventorSheng-Ping Zhong
Life of this patent
Estimating the term…
Abstract
According to an aspect of the present invention, medical articles are provided, which are at least partially biodegradable. The medical articles comprise (a) biodegradable polymers that produce acidic molecules upon degradation; and (b) acid neutralizing cationic species.
Claims23
A medical article comprising
- (a) a biodegradable polymer that produces acidic molecules upon degradation within a subject;
- and
- (b) an acid neutralizing cationic species,
- wherein said cationic species is a polycationic polymer,
- wherein said biodegradable polymer and said acid neutralizing cationic species are blended within a polymeric region in the form of a biodegradable coating that is provided over a metallic or ceramic substrate, said medical article being an implantable or insertable medical article, and
- wherein said medical article comprises a single therapeutic agent as the only therapeutic species, which therapeutic agent is not electrostatically bound to or entrapped within said cationic species, which therapeutic agent is selected from an uncharged therapeutic agent and a cationic therapeutic agent, and which is released from said article within said subject.
3 more elements
A medical article comprising:
- (a) a biodegradable polymer that produces acidic molecules upon degradation within a subject;
- and
- (b) an acid neutralizing cationic species which is a polycationic polymer selected from polyamines, polyimines and polycationic polysaccharides,
- wherein said biodegradable polymer and said acid neutralizing cationic species are blended within a polymeric region in the form of a biodegradable coating that is provided over a substrate, said medical article being an implantable or insertable medical article, and
- wherein said medical article comprises a single therapeutic agent as the only therapeutic species, which therapeutic agent is not electrostatically bound to or entrapped within said cationic species, which therapeutic agent is selected from an uncharged therapeutic agent and a cationic therapeutic agent, and which is released from said article within said subject.
2 more elements
A medical article comprising
- (a) a biodegradable polymer that produces acidic molecules upon degradation within a subject;
- and
- (b) an acid neutralizing cationic species in the form of a polycationic dendrimer,
- wherein said biodegradable polymer and said acid neutralizing cationic species are blended within a polymeric region, said medical article being an implantable or insertable medical article, and
- wherein said medical article comprises a single therapeutic agent as the only therapeutic species, which therapeutic agent is not electrostatically bound to or entrapped within said cationic species, which therapeutic agent is selected from an uncharged therapeutic agent and a cationic therapeutic agent, and which therapeutic agent is released from said article within said subject.
2 more elements
Dependencies are inferred from the claim text.