Drug delivery coating for use with a stent
AssigneeAtrium Medical Corporation
InventorsRoger Labrecque, Geoffrey Moodie, Joseph Ferraro, Lisa Rogers, Paul Martakos, Theodore Karwoski, Steve A. Herweck
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Abstract
A coated medical device an a method of providing a coating on an implantable medical device result in a medical device having a bio-absorbable coating. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component can also be provided. The coated medical device is implantable in a patient to effect controlled delivery of the coating, including the therapeutic agent, to the patient.
Claims56
A coated medical device, comprising:
- a coating having cross-linked bio-absorbable carrier component, the bio-absorbable carrier component being at least partially formed of cellular uptake inhibitor and cellular uptake enhancer;
- wherein the cellular uptake enhancer comprises one or more fatty acids selected from the group consisting of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and alpha-linolenic acid (ALA);
- wherein the coating is cured using at least one of heat and ultraviolet light and further includes a therapeutic agent;
- wherein the bioabsorbable carrier component comprises two or more of the fatty acids cross-linked into a substantially random configuration by ester bonds;
- and controlled delivery of the therapeutic agent to the patient.
A coated medical device, comprising:
- a pre-treatment provided on the medical device having a first bio-absorbable carrier component;
- and
- a coating disposed on top of the pre-treatment, the coating having a cross-linked second bioabsorbable carrier component at least partially formed of cellular uptake inhibitor and cellular uptake enhancer;
- wherein the cellular uptake enhancer comprises one or more fatty acids selected form the group consisting of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and alpha-linolenic acid (ALA);
- wherein the coating is cured using at least one of heat and ultraviolet light and further includes a therapeutic agent;
- wherein the bio-absorbable carrier component comprises two or more of the fatty acids cross-linked into a substantially random configuration by ester bonds;
- wherein the pre-treatment improves consistency and conformability and enhances the adhesion of the coating comprising the second bio-absorbable carrier component;
- and
- wherein the coated medical device is implantable in a patient to effect controlled delivery of the therapeutic agent to the patient.
Dependencies are inferred from the claim text.