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US 8,263,101 B2Granted
Passive methods for anti-microbial biological meshes
AssigneeLifeCell Corporation
InventorsRick T. Owens, Mike Liu, Yong Mao
Life of this patent
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Abstract
Tissue matrices having anti-microbial properties are provided. In certain embodiments, the tissue matrices include cationic anti-microbial agents that form a stable bond with the tissue matrices without adversely affecting the biologic properties of the tissue matrices.
Claims27
An anti-microbial tissue matrix prepared by:
- selecting a collagen-based tissue;
- and
- contacting the tissue with an aqueous solution containing a cationic anti-microbial agent, wherein the agent is stably bound to a tissue matrix within the collagen-based tissue by passive adsorption in the aqueous solution, and wherein the tissue has been exposed to E-beam radiation.
An anti-microbial tissue matrix comprising:
- a collagen-based tissue;
- and
- at least one cationic anti-microbial agent that is stably bound to the collagen-based tissue by passive adsorption in an aqueous solution, and wherein the collagen-based tissue has been exposed to E-beam radiation.
Dependencies are inferred from the claim text.