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US 8,263,094 B2Granted
Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids and preparation thereof
AssigneeEastman Chemical Company
InventorsMichael Fitzpatrick Wempe, Liu Deng, Stephanie Kay Clendennen, Neil Warren Boaz
Life of this patent
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Abstract
Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids were prepared chemically and/or enzymatically. Depending upon the ester, improved melanocyte cytotoxicity was achieved. Improved cytotoxicity characteristics are consistent with ester analogs being more physiologically compatible and less irritating to skin than their corresponding acids.
Claims7
A composition, comprising an ester and a dermatologically acceptable carrier, wherein the ester is represented by the general formula 1:
- wherein R and R1 are each independently a C1-C4 alkyl, R2 is a C6-C22 alkyl, C6-C22 alkenyl, C6-C20 dienyl, C6-C22 trienyl, C8-C22 tetraenyl or a mixture thereof, and n is 2-18.
Dependencies are inferred from the claim text.