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US 8,263,093 B2Granted
Methods and compositions for administration of TRPV1 agonists
AssigneeNeurogesX, Inc.
InventorsNaweed Muhammad, Gene Curtis Jamieson, Keith R. Bley, Sanjay Chanda
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Abstract
Compositions are provided that contain a TRPV1 agonist, such as capsaicin, and a solvent system. Topical application of the composition results in rapid delivery of agonist to the dermis and epidermis. Method of using the compositions for reducing nociceptive nerve fiber function in subjects, and for treatment of capsaicin-responsive conditions are also provided.
Claims11
A liquid formulation for treating neuropathic pain associated with a condition comprising:
- about 6% (w/v) to about 20% (w/v) capsaicin;
- and
- a solvent system, the solvent system comprising about 10% (v/v) to about 25% (v/v) oleyl alcohol and the remainder propylene glycol.
Dependencies are inferred from the claim text.