Clostridial toxin NetB
AssigneeAustralian Poultry Crc Pty Ltd
InventorsRobert John Moore, Julian Ian Rood, Anthony Leslie Keyburn
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Abstract
The present invention relates to a polypeptide based toxin that originates from Clostridium perfringens. The invention further relates to immunogenic compositions comprising the toxin and methods to vaccinate animals, for example chickens, such that they are less susceptible to clostridial diseases. Methods to determine whether an animal has been exposed to the toxin, polynucleotides encoding the toxin and attenuated bacteria that express a reduced or less active form of the toxin are also disclosed.
Claims9
A substantially purified and/or recombinant polypeptide, wherein the polypeptide comprises:
- i) the amino acid sequence as provided in SEQ ID NO:2,
- ii) an amino acid sequence which is at least 95% identical to SEQ ID NO:2, and/or
- iii) an antigenic fragment of i) which is at least 10 amino acids in length.
Dependencies are inferred from the claim text.