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US 8,263,081 B2Granted
Antibody-light fusion products for cancer therapeutics
AssigneeThe University of Chicago
InventorYang-Xin Fu
Life of this patent
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Abstract
Antibody-LIGHT fusion products or conjugates stimulate immunity against tumors and eradicate metastases. Tumor-specific antibodies coupled with LIGHT effectively target metastatic tumors and reduces cancer metastases.
Claims23
A composition comprising a tumor specific antibody linked to a fragment of a human LIGHT protein, wherein the LIGHT fragment is resistant to protease digestion and stimulates cytotoxic T lymphocytes against tumor cells.
Dependencies are inferred from the claim text.