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US 8,263,080 B2Granted
Use of agonists and antagonists of IL-23 in the treatment of viral infection
AssigneeSchering Corporation
InventorsPeter D. Katsikis, Ioannis Dimitriou, Daniel J. Cua
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Abstract
Provided are methods of modulating cytokine activity, e.g., for the purpose of treating viral infections. Also provided are reagents for use in screening for agonists or antagonists of IL-23.
Claims13
A method of modulating CD8+ T cell response to a viral infection comprising administering an effective amount of an antagonist of IL-23, wherein:
- i) the antagonist of IL-23 specifically binds to p19 or IL-23R;
- ii) the viral infection is caused by:
- a) a respiratory virus;
- b) a mucosal virus;
- or
- c) an influenza virus;
- and
- iii) said modulating CD8+ T cell response comprises increasing the ex vivo cytotoxicity of CD8+ T cells,
- wherein the antagonist comprises an antibody or a fragment thereof that specifically binds to p19 or IL-23R.
6 more elements
Dependencies are inferred from the claim text.