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US 8,263,076 B2Granted
Anti-inflammatory dAb
AssigneeCephalon Australia Pty Ltd
InventorsBenjamin P. Woolven, Ian M. Tomlinson, Jennifer A. Lee, Anthony G. Doyle, Philip A. Jennings
Life of this patent
Estimating the term…
Abstract
The present invention provides a recombinant domain antibody (dAb) which binds to human TNFα, the dAb comprising an immunoglobulin heavy or light chain variable domain comprising at least one complementarity determining region (CDR) having a sequence derived from a New World primate.
Claims16
A recombinant domain antibody (dAb) which specifically binds to TNF-α, wherein the dAb has a sequence consisting of
- (SEQ ID NO:
- 7)
- DIQMTQSPSSLSASVGDRVTITCRASQSIDSYLHWYQQKPGKAPKLLIYSA
- SNLETGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQVVWRPFTFGQGT
- KVEIKR.
2 more elements
A recombinant domain antibody (dAb) which specifically binds to TNF-α, wherein the dAb comprises the amino acid sequence
- (SEQ ID NO:
- 7)
- DIQMTQSPSSLSASVGDRVTITCRASQSIDSYLHWYQQKPGKAPKLLIYSA
- SNLETGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQVVWRPFTFGQGT
- KVEIKR.
2 more elements
Dependencies are inferred from the claim text.