Antibody molecule for human GM-CSF receptor alpha
AssigneeMedImmune, LLC
InventorsEmma Suzanne Cohen, Ralph Raymond Minter, Paula Rosamund Harrison, Matthew Alexander Sleeman, Andrew Donald Nash, Louis Jerry Fabri
Life of this patent
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Abstract
Binding members are provided for alpha chain of receptor for granulocyte macrophage colony stimulating factor (GM-CSFRα), especially antibody molecules. Use of the binding members in treating inflammatory and autoimmune diseases, e.g. rheumatoid arthritis, asthma, allergic response, multiple sclerosis, myeloid leukaemia and atherosclerosis is also provided.
Claims10
An isolated antibody molecule for human GM-CSFRα, which inhibits binding of GM-CSF to GM-CSFRα, and which comprises a VH domain with the VH domain amino acid sequence shown in SEQ ID NO:
- 52 and a VL domain with the VL domain amino acid sequence shown in SEQ ID NO:
- 218.
An isolated antibody molecule, wherein the antibody molecule comprises an antibody VH domain and an antibody VL domain, the antibody VH domain comprising heavy chain complementarity determining regions (CDRs) HCDR1, HCDR2 and HCDR3 and the VL domain comprising light chain CDRs LCDR1, LCDR2 and LCDR3, wherein the amino acid sequences of the CDRs are:
- HCDR1 SEQ ID NO:
- 3
- HCDR2 SEQ ID NO:
- 4
- HCDR3 SEQ ID NO:
- 55
- LCDR1 SEQ ID NO:
- 8
- LCDR2 SEQ ID NO:
- 9, and
- LCDR3 SEQ ID NO:
- 60.
An isolated antibody molecule for human GM-CSFRα, which inhibits binding of GM-CSF to GM-CSFRα, and which comprises:
- a VH domain with the VH domain amino acid sequence shown in SEQ ID NO:
- 52, or comprises that VH domain with one or two conservative amino acid substitutions, and
- a VL domain with the VL domain amino acid sequence shown in SEQ ID NO:
- 218, or comprises that VL domain with one or two conservative amino acid substitutions.
Dependencies are inferred from the claim text.