Fibroblast growth factor receptor-1 inhibitors and methods of treatment thereof
AssigneeImClone LLC
InventorsHaijun Sun, Juqun Shen, James Robert Tonra
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Abstract
The present invention is directed to an antibody or fragments thereof that are specific for a fibroblast growth factor receptor (FGFR)-1(IIIb), FGFR-1(IIIc), and/or FGFR-4. Also, provided herein, are vectors and host cells comprising the nucleic acids encoding those antibodies. The present invention further provides methods of antagonizing FGFR-1 or FGFR-4 as a treatment for obesity, diabetes, or a condition related thereto, and methods of reducing food intake.
Claims6
An antibody, or Fv (fragment variable) thereof, comprising a heavy chain variable region (VH) and a light chain variable region (VL), wherein the VH comprises complementarity determining regions (CDRs) VH CDR1, VH CDR2, and VH CDR3 and wherein the VL comprises CDRs VL CDR1, VL CDR2, and VL CDR3, wherein VH CDR1 is SEQ ID NO:1, VH CDR2 is SEQ ID NO:
- 2, VH CDR3 is SEQ ID NO:
- 3, VL CDR1 is SEQ ID NO:
- 4, VL CDR2 is SEQ ID NO:
- 5, and VL CDR3 is SEQ ID NO:
- 6, wherein the antibody or Fv thereof binds to FGFR1(IIIc).
Dependencies are inferred from the claim text.