Compositions including anthocyanin or anthocyanidin for the prevention or treatment of articular cartilage-associated conditions
OwnerLanny L. Johnsoninventor
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Abstract
Methods of treating an arthritic joint of a subject, including administering a pharmaceutical composition by injection into the arthritic joint, wherein the composition includes an anthocyanin or anthocyanidin, glucose, and a pharmaceutically acceptable carrier.
Claims6
A method of treating an arthritic joint of a subject, comprising:
- a) excising synovial villi from a synovial capsule of a joint;
- b) culturing by combining the synovial villi with a composition comprising an anthocyanin and optionally glucose or an anthocyanidin and optionally glucose;
- and
- c) introducing the cultured synovial villi to the arthritic joint.
A method of treating an arthritic joint of a subject, comprising:
- a) excising synovial villi from a synovial capsule of a joint to provide an explant;
- b) introducing the explant to the arthritic joint;
- and
- c) administering a composition intra-articularly to the arthritic joint, wherein the composition comprises an anthocyanin and optionally glucose or an anthocyanidin and optionally glucose.
A method of treating an arthritic joint of a subject, comprising:
- a) harvesting mesenchymal stem cells from synovium;
- b) culturing the stem cells with a composition comprising an anthocyanin or anthocyanidin;
- and optionally glucose;
- and
- c) introducing the cultured stem cells to the arthritic joint.
A method for increasing expression of IGF-1 in a cartilage explant, comprising providing a cartilage explant from a patient suffering from osteoarthritis and administering to the explant a composition comprising an anthocyanin and glucose or an anthocyanidin and glucose.
Dependencies are inferred from the claim text.