Fast degrading polymers
AssigneeRutgers, The State University of New Jersey
InventorsKathryn E. Uhrich, Young Mi Kim
Life of this patent
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Abstract
The invention provides polyanhydrides that degrade in less than 60 hours following topical administration to deliver biologically active compounds.
Claims27
A composition suitable for topical administration to an animal comprising a polyanhydride homopolymer having a backbone that degrades within 60 hours of administration to provide a biologically active compound, wherein the biologically active compound is p-coumaric acid, ferulic acid, or sinapic acid.
A composition suitable for topical administration comprising microspheres that degrade within 60 hours of administration, the microspheres comprising a polyanhydride homopolymer having a backbone that comprises one or more groups that will provide p-coumaric acid, ferulic acid, or sinapic acid upon hydrolysis of the backbone.
A composition suitable for topical administration to an animal comprising a polyanhydride homopolymer having a backbone that degrades within 60 hours of administration to provide a biologically active compound, wherein the polyanhydride comprises one or more units of the following formula:
- wherein:
- each R1 is independently H, or methoxy;
- and
- L is a divalent, branched or unbranched, saturated or unsaturated, hydrocarbon chain, having from 1 to 20 carbon atoms, wherein the chain is optionally substituted on carbon with one or more (e.g. 1, 2, 3, or 4) substituents selected from the group consisting of (C1-C6)alkoxy, (C3-C6)cycloalkyl, (C1-C6)alkanoyl, (C1-C6)alkanoyloxy, (C1-C6)alkoxycarbonyl, (C1-C6)alkylthio, azido, cyano, nitro, halo, hydroxy, oxo, carboxy, aryl, aryloxy, heteroaryl, and heteroaryloxy.
A polyanhydride homopolymer that comprises units of the following formula (I):
- wherein:
- each R1 is independently H, or methoxy;
- and
- L is a divalent, branched or unbranched, saturated or unsaturated, hydrocarbon chain, having from 1 to 20 carbon atoms, wherein the chain is optionally substituted on carbon with one or more (e.g. 1, 2, 3, or 4) substituents selected from the group consisting of (C1-C6)alkoxy, (C3-C6)cycloalkyl, (C1-C6)alkanoyl, (C1-C6)alkanoyloxy, (C1-C6)alkoxycarbonyl, (C1-C6)alkylthio, azido, cyano, nitro, halo, hydroxy, oxo, carboxy, aryl, aryloxy, heteroaryl, and heteroaryloxy.
A composition suitable for topical administration to an animal comprising a polyanhydride homopolymer having a backbone that degrades within 60 hours of administration to provide a biologically active compound, wherein the polyanhydride comprises one or more units of the following formula:
- wherein:
- each R1 is independently H, or methoxy;
- and
- L is —CH2CH2CH2CH2—.
Dependencies are inferred from the claim text.