US 8,263,048 B2 · Calcium phosphate complex for oral care applications, its preparation method, and compositions containing the same

Abstract

The invention is directed to a calcium phosphate complex and the composition containing the same for oral care applications, in which the calcium phosphate complex is formed by chelating the γ-polyglutamic acid (γ-PGA) with amorphous calcium phosphate (ACP). This complex can prevent crystallization of ACP and maintain its high solubility. The calcium phosphate complex has superior mucoadhesion properties, allowing it to remain in the mouth longer and offering effective buffering, by which dental caries can be alleviated and prevented.

Claims22

Dependent claims

An oral composition, comprising a γ-polyglutamic acid (γ-PGA) calcium phosphate complex formed by chelating γ-polyglutamic acid (γ-PGA) with amorphous calcium phosphate (ACP), wherein the ratio of γ-PGA to ACP is about 5% to about 95%:about 95% to about 5%.

Dependencies are inferred from the claim text.

Facts

Application

12/975,052Filed 21 Dec 2010

Priority

TW 98144259 A22 Dec 2009

Published

US 2011/0150791 A123 Jun 2011

Granted

11 Sep 2012

Term ends

Not estimatedThe source records don’t support an estimate.

Classification6 codes

A61K 8/88
Obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds: polyamides
A61K 8/24
Containing inorganic ingredients: phosphorous; Compounds thereof
A61Q 11/00
Preparations for care of the teeth, of the oral cavity or of
A61K 2800/58
Chemical, physico-chemical or functional or structural properties of particular ingredients: metal complex; Coordination compounds

Calcium phosphate complex for oral care applications, its preparation method, and compositions containing the same

Life of this patent

Calcium phosphate complex for oral care applications, its preparation method, and compositions containing the same

Life of this patent

Abstract

Claims22