N-phenyl-N-pyridinyl-benzamides and benzenesulfonomides having cooling properties
AssigneeGivaudan SA
InventorsChristophe C. Galopin, Lori W. Tigani, Jay Patrick Slack, Pablo Victor Krawec, Lucienne Cole
Life of this patent
Estimating the term…
Abstract
Used as cooling agents are the compounds of formula (I), wherein Y is carbonyl (C(═O)) or sulfonyl (SO2—); and X is OCH3, CN, C(═O)NHR, C(═O)OR, or halogen; and R is hydrogen or C1-C4 alkyl.
Claims15
A method of providing a cooling effect to the skin or mucous membranes by applying thereto an effective amount of a compound of formula (I)
- wherein
- Y is carbonyl (—C(═O)—) or sulfonyl (—SO2—);
- X is —O—CH3, —CN, —C(═O)NHR, —C(═O)OR, or halogen;
- and
- R is hydrogen or C1-C4 alkyl;
- with the proviso that Y is not sulfonyl if X is chlorine.
A method of providing a cooling effect to the skin or mucous membranes by applying thereto a product comprising at least one compound selected from the group consisting of of compounds of formula (I)
- wherein
- Y is carbonyl (—C(═O)—) or sulfonyl (—SO2—);
- X is —O—CH3, —CN, —C(═O)NHR, —C(═O)OR, or halogen;
- and
- R is hydrogen or C1-C4 alkyl;
- with the proviso that Y is not sulfonyl if X is chlorine.
A product that provides a cooling effect to the skin or mucous membranes, which product comprises an effective amount of at least one compound of formula (I)
- wherein
- Y is carbonyl (—C(═O)—) or sulfonyl (—SO2—);
- X is —O—CH3, —CN, —C(═O)NHR, —C(═O)OR, or halogen;
- and
- R is hydrogen or C1-C4 alkyl;
- with the proviso that Y is not sulfonyl if X is chlorine.
A product selected from the group consisting of topical products, oral care products, nasal care products, toilet articles, ingestible products and chewing gum, comprising a product base and an effective amount of a cooling compound of formula (I)
- wherein
- Y is carbonyl (—C(═O)—) or sulfonyl (—SO2—);
- X is —O—CH3, —CN, —C(═O)NHR, —C(═O)OR, or halogen;
- and
- R is hydrogen or C1-C4 alkyl, or a mixture thereof;
- with the proviso that Y is not sulfonyl if X is chlorine.
A compound selected from the group consisting of 4-methoxy-N-phenyl-N-[2-(pyridin-2-yl)ethyl]benzamide, 4-methoxy-N-phenyl-N-[2-(pyridin-2-yl)ethyl]benzenesulfonamide, and 4-cyano-N-phenyl-N[2-(pyridin-2-yl)ethyl]benzenesulfonamide.
A method of providing a cooling effect to the skin or mucous membranes by applying thereto an effective amount of a compound which is selected from the group consisting of 4-methoxy-N-phenyl-N-[2-(pyridin-2-yl)ethyl]benzamide, 4-methoxy-N-phenyl-N[2-(pyridin-2-yl)ethyl]benzenesulfonamide, 4-chloro-N-phenyl-N-[2-(pyridin-2-yl)ethyl]benzenesulfonamide and 4-cyano-N-phenyl-N-[2-(pyridin-2-yl)ethyl]benzenesulfonamide.
A method of providing a cooling effect to the skin or mucous membranes by applying thereto a product comprising an effective amount of at least one compound which is selected from the group consisting of 4-methoxy-N-phenyl-N-[2-(pyridin-2-yl)ethyl]benzamide, 4-methoxy-N-phenyl-N-[2-(pyridin-2-yl)ethyl]benzenesulfonamide, 4-chloro-N-phenyl-N[2-(pyridin-2-yl)ethyl]benzenesulfonamide and 4-cyano-N-phenyl-N-[2-(pyridin-2-yl)ethyl]benzenesulfonamide.
A product that provides a cooling effect to the skin or mucous membranes, which product comprises an effective amount of at least one compound which is selected from the group consisting of 4-methoxy-N-phenyl-N-[2-(pyridin-2-yl)ethyl]benzamide, and 4-cyano-N-phenyl-N-[2-(pyridin-2-yl)ethyl]benzenesulfonamide.
A product selected from the group consisting of topical products, oral care products, nasal care products, toilet articles, ingestible products and chewing gum, comprising a product base and an effective amount of a cooling compound which is selected from the group consisting of 4-methoxy-N-phenyl-N-[2-(pyridin-2-yl)ethyl]benzamide, 4-methoxy-N-phenyl-N-[2-(pyridin-2-yl)ethyl]benzenesulfonamide, 4-chloro-N-phenyl-N-[2-(pyridin-2-yl)ethyl]benzenesulfonamide and 4-cyano-N-phenyl-N-[2-(pyridin-2-yl)ethyl]benzenesulfonamide.
Dependencies are inferred from the claim text.