Contrast agents for myocardial perfusion imaging
AssigneeLantheus Medical Imaging, Inc.
InventorsHeike S. Radeke, David S. Casebier, Michael T. Azure, Douglas D. Dischino
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Abstract
The present disclosure is directed, in part, to compounds and methods for imaging myocardial perfusion, comprising administering to a patient a contrast agent which comprises a compound that binds MC-1, and an imaging moiety, and scanning the patient using diagnostic imaging.
Claims19
A contrast agent comprising an imaging moiety and an open-chain deguelin analog, wherein the open-chain deguelin analog is an analog of deguelin having the structure:
- and at least one of rings C and D is not present or is replaced by a linker connecting the remaining rings.
A method of imaging myocardial perfusion, comprising:
- administering to a patient a contrast agent which comprises an imaging moiety and an open-chain deguelin analog;
- and
- scanning the patient using diagnostic imaging, wherein the open-chain deguelin analog is an analog of deguelin having the structure:
- and at least one of rings C and D is not present or is replaced by a linker connecting the remaining rings.
A contrast agent of formula (III):
- J is S, C(R37)2, or O;
- ------ is a single or double bond;
- and
- R30, R31, R32, R33, R34, R35, R36, R37, R38, R39, R40, R41, and R42 are independently at each occurrence hydrogen, C1-C6 alkyl optionally substituted with an imaging moiety, C1-C6 alkoxy optionally substituted with an imaging moiety, or an imaging moiety;
- provided that when ------ is a double bond, R31 and R32 are absent;
- and
- provided at least one imaging moiety is present in formula (III).
A method of imaging myocardial perfusion, comprising:
- administering to a patient a contrast agent;
- and
- scanning the patient using diagnostic imaging, wherein the contrast agent is of formula (III):
- J is S, C(R37)2, or O;
- ------ is a single or double bond;
- and
- R30, R31, R32, R33, R34, R35, R36, R37, R38, R39, R40, R41, and R42 are independently at each occurrence hydrogen, C1-C6 alkyl optionally substituted with an imaging moiety, C1-C6 alkoxy optionally substituted with an imaging moiety, or an imaging moiety;
- provided that when ------ is a double bond, R31 and R32 are absent;
- and
- provided at least one imaging moiety is present in formula (III).
Dependencies are inferred from the claim text.