Antigen associated with the neovasculature of tumour metastases

A method of delivering a molecule to the neovasculature of tumour metastases in a human or animal comprising administering to the human or animal an antibody which binds the ED-A isoform of fibronectin comprising:

• a VH domain comprising a framework and a set of complementarity determining regions HCDR1, HCDR2 and HCDR3, wherein:
• HCDR1 has the amino acid sequence of SEQ ID NO:83,
• HCDR2 has the amino acid sequence of SEQ ID NO:
• 4, and
• HCDR3 has the amino acid sequence of SEQ ID NO:
• 5, and
• a VL domain comprising a framework and a set of complementarity determining regions LCDR1, LCDR2 and LCDR3, wherein:
• LCDR1 has the amino acid sequence of SEQ ID NO:86,
• LCDR2 has the amino acid sequence of SEQ ID NO:
• 7, and
• LCDR3 has the amino acid sequence of SEQ ID NO:
• 8;
• wherein the antibody is conjugated to the molecule.