Metal chelates having a perfluorinated PEG radical, processes for their preparation, and their use

A metal chelate selected from:

• 6-N-[1,4,7-Tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecane-10-N-(pentanoyl-3-aza-4-oxo-5-methyl-5-yl)]-2-N-(1-O-α-d-carbonylmethylmannopyranose)-L-lysine-[N-methyl-(1H,1H,2H,2H,4H,4H,-3,6,9,12-tetraoxaperfluoro-hexadecyl)]amide, complexes with at least one metal ion equivalent of atomic number 57-83;
• 1,4,7-Tris(carboxylatomethyl)-10-[(3-aza-4-oxo-5-methyl-5-yl)-acid N-(1H,1H,2H, 2H,-4H,4H,-3,6,9,12-tetraoxaperfluorohexadecyl)-N-(2-methoxyethyl)amide]-1,4,7,10-tetra-azacyclododecane, complexes with at least one metal ion equivalent of atomic number 57-83;
• 6-N-[1,4,7-Tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecane-10-N-(pentanoyl-3-aza-4-oxo-5-methyl-5-yl)]-2-N-(1-O-α-d-carbonylmethylmannopyranose)-L-lysine[N-methyl-(1H,1H,2H,2H,4H,4H,-3,6,9,12-tetraoxaperfluoro-tridecyl)]amide, complexes with at least one metal ion equivalent of atomic number 57-83;
• 1,4,7-Tris(carboxylatomethyl)-10-[(3-aza-4-oxo-5-methyl-5-yl)acid N-(1H,1H,2H,2H,-4H,4H,-3,6,9,12-tetraoxaperfluorotridecyl)-N-(2-methoxyethyl)amide]1,4,7,10-tetra-azacyclododecane, complexes with at least one metal ion equivalent of atomic number 57-83;
• 6-N-[1,4,7-Tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecane-10-N-(pentanoyl-3-aza-4-oxo-5-methyl-5-yl)]-2-N-(1-O-α-d-carbonylmethylmannopyranose)-L-lysine[N-methyl-(2H,2H,4H,4H,-3,6,9,12-tetraoxa-5,8,11-trimethyl-perfluoropentadecyl)]amide, complexes with at least one metal ion equivalent of atomic number 57-83;
• 1,4,7-Tris(carboxylatomethyl)-10-[(3-aza-4-oxo-5-methyl-5-yl)acid N-(2H,2H,4H, 4H,-3,6,9,12-tetraoxa-5,8,11-trimethylperfluoropentadecyl)-N-(2-methoxyethyl)amide]1,4,7,10-tetra-azacyclododecane, complexes with at least one metal ion equivalent of atomic number 57-83;
• 6-N-[1,4,7-Tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecane-10-N-(pentanoyl-3-aza-4-oxo-5-methyl-5-yl)]-2-N-(1-O-α-d-carbonylmethylmannopyranose)-L-lysine[N-methyl-(3,6,9,12,15-pentaoxa-5,8,11,14-tetramethyl-perfluorooctadecyl)]amide, complexes with at least one metal ion equivalent of atomic number 57-83;
• 1,4,7-Tris(carboxylatomethyl)-10-[(3-aza-4-oxo-5-methyl-5-yl)acid N-(3,6,9,12,15-pentaoxa-5,8,11,14-tetramethylperfluorooctadecyl)-N-(2-methoxyethyl)amide]1,4,7,10-tetra-azacyclododecane, complexes with at least one metal ion equivalent of atomic number 57-83;
• N-{[1,4,7-Tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecane-10-N-(pentanoyl-3-aza-4-oxo-5-methyl-5-yl)]-2-aminoethyl}-N-(1H,1H,2H,2H,4H,4H-3,6,9,12-tetraoxa-perfluorotridecyl)-2-[2-(2-methoxyethoxy)ethoxy]acetamide, complexes with at least one metal ion equivalent of atomic number 57-83;
• N-{[1,4,7-Tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecane-10-N-(pentanoyl-3-aza-4-oxo-5-methyl-5-yl)]-2-aminoethyl}-N-(1H,1H,2H,2H,4H,4H-6,9,12,15-tetraoxa-8,11,14-trimethylperfluoropentadecyl)-2-[2-(2-methoxyethoxy)ethoxy]-acetamide, complexes with at least one metal ion equivalent of atomic number 57-83;
• 6-N-(1-O-α-d-Carbonylmethylmannopyranose)-2-N-(2H,2H,4H,4H-3,6,9,12,-tetraoxaperfluorotridecanoyl)-L-lysine[1,4,7-tris-(carboxylatomethyl)-1,4,7,10-tetraazacyclododecane-10-N-(2-hydroxy-3-yl)]amide, complexes with at least one metal ion equivalent of atomic number 57-83;
• 6-N-{2-[2-(2-Methoxyethoxy)ethoxy]acetyl}-2-N-(2H,2H,4H,4H-3,6,9,12,-tetraoxa-5,8,11-trimethylperfluoropentadecanoyl)-L-lysine[1,4,7-tris-(carboxylatomethyl)-1,4,7,10-tetraazacyclododecane-10-N-(2-hydroxy-3-yl)]amide, complexes with at least one metal ion equivalent of atomic number 57-83;
• 6-N-[1,4,7-Tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecane-10-N-(pentanoyl-3-aza-4-oxo-5-methyl-5-yl)]-2-N-(2H,2H,4H,4H-3,6,9,12,-tetraoxa-perfluorotridecanoyl)-L-lysine(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethyl)amide, complexes with at least one metal ion equivalent of atomic number 57-83;
• 3,5-N,N′-Bis[1,4,7-tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecane-10-N-(pentanoyl-3-aza-4-oxo-5-methyl-5-yl)]-benzoic acid [(1H,1H,2H,2H,4H,4H,-3,6,9,12-tetraoxaperfluorotridecyl)methyl]amide, complexes with at least one metal ion equivalent of atomic number 57-83;
• N-[1,4,7-Tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecane-10-N-(pentanoyl-3aza-4-oxo-5-methyl-5-yl)]-3-{2-[2-(2-methoxyethoxy)ethoxy]ethyl}-L-serine 1-[(1H,1H,2H,2H,4H,4H,-3,6,9,12-tetraoxaperfluorotridecyl)methyl]amide, complexes with at least one metal ion equivalent of atomic number 57-83;
• L-Glutamic acid 5-{[1,4,7-tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecane-10-N-(2-hydroxy-3-yl)]amido}-N-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}acetyl)-1-[(1H,1H,2H,2H,4H,4H,-3,6,9,12-tetraoxaperfluorotridecyl)methyl]amide, complexes with at least one metal ion equivalent of atomic number 57-83;
• N-[1,4,7-Tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecane-10-N-(pentanoyl-3-aza-4-oxo-5-methyl-5-yl)]-L-glutamic acid 5-(2-{2-[2-(2-methoxyethoxy)ethoxy]-ethoxy}ethyl)amide 1-[(1H,1H,2H,2H,4H,4H,-3,6,9,12-tetraoxaperfluorotridecyl)-methyl]amide, complexes with at least one metal ion equivalent of atomic number 57-83;
• L-2-[1,4,7-Tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecane-10-N-(pentanoyl-3-aza-4-oxo-5-methyl-5-yl)]-amino-4-(2-{2-[2-(2-methoxyethoxy)ethoxy]-ethoxy}acetyl)aminobutyric acid [(1H,1H,2H,2H,4H,4H,-3,6,9,12-tetraoxaperfluoro-tridecyl)methyl]amide, complexes with at least one metal ion equivalent of atomic number 57-83;
• 2-N-[1,4,7-Tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecane-10-N-(pentanoyl-3-aza-4-oxo-5-methyl-5-yl)]-6-N-benzyloxycarbonyl-L-lysine[N-methyl-(1H,1H,2H,2H,4H,4H,-3,6,9,12-tetraoxaperfluorohexadecyl)]amide, complexes with at least one metal ion equivalent of atomic number 57-83;
• 2-N-[1,4,7-Tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecane-10-N-(pentanoyl-3-aza-4-oxo-5-methyl-5-yl)]-L-lysine[N-methyl-(1H,1H,2H,2H,4H,4H,-3,6,9,12-tetraoxaperfluorohexadecyl)]amide, complexes with at least one metal ion equivalent of atomic number 57-83;
• 2-N-[1,4,7-Tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecane-10-N-(pentanoyl-3-aza-4-oxo-5-methyl-5-yl)]-6-N-(1-O-α-d-carbonylmethylmannopyranose)-L-lysine[N-methyl-(1H,1H,2H,2H,4H,4H,-3,6,9,12-tetraoxaperfluorohexadecyl)]amide, complexes with at least one metal ion equivalent of atomic number 57-83;
• 2-N-[1,4,7-Tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecane-10-N-(pentanoyl-3-aza-4-oxo-5-methyl-5-yl)]-6-N-{2-[2-(2-methoxyethoxy)ethoxy]acetyl}-L-lysine[N-methyl-(1H,1H,2H,2H,4H,4H,-3,6,9,12-tetraoxaperfluorohexadecyl)]-amide, complexes with at least one metal ion equivalent of atomic number 57-83;
• 1,4,7-Tris(carboxylatomethyl)-10-{(3-aza-4-oxo-5-methyl-5-yl)-acid-N-(1H,1H,2H,2H,-4H,4H,-3,6,9,12-tetraoxaperfluorohexadecyl)-N-[2-(2-methoxyethoxy)ethyl]amide}-1,4,7,10-tetraazacyclododecane, complexes with at least one metal ion equivalent of atomic number 57-83;
• 1,4,7-Tris(carboxylatomethyl)-10-[(3-aza-4-oxo-5-methyl-5-yl)acid N-(1H,1H,2H,2H, 4H,4H,-3,6,9,12-tetraoxaperfluorohexadecyl)-N-{2-[2-(2-methoxyethoxy)ethoxy]-ethyl}amide]1,4,7,10-tetraazacyclododecane, complexes with at least one metal ion equivalent of atomic number 57-83;
• 1,4,7-Tris(carboxylatomethyl)-10-{[(3-aza-4-oxo-5-methyl-5-yl)acid N-(1H,1H,2H, 2H,-4H,4H,-3,6,9,12-tetraoxaperfluorohexadecyl)-N-[2-(1-O-α-d-mannopyranosyl)ethyl]amide}1,4,7,10-tetraazacyclododecane, complexes with at least one metal ion equivalent of atomic number 57-83;
• 1,4,7-Tris(carboxylatomethyl)-10-[(4-hydroxy-5-yl)acid N-(1H,1H,2H,2H,4H,4H,-3,6,9,12-tetraoxaperfluorohexadecyl)-N-(2-methoxyethyl)amide]1,4,7,10-tetraaza-cyclododecane, complexes with at least one metal ion equivalent of atomic number 57-83;
• 1,4,7-Tris(carboxylatomethyl)-10-[(3-aza-4-oxo-5-methyl-5-yl)acid N-(1H,1H,2H,2H, 4H,4H,-3,6,9,12-tetraoxaperfluorohexadecyl)-N-(2-methoxyethyl)amide]-1,4,7,10-tetra-azacyclododecane, complexes with at least one metal ion equivalent of atomic number 57-83;
• 1,4,7-Tris(carboxylatomethyl)-10-[(3-aza-4-oxo-5-methyl-5-yl)acid N-(1H,1H,2H, 2H,-4H,4H,-3,6,9,12-tetraoxaperfluorohexadecyl)-N-(2-methoxyethyl)amide]1,4,7,10-tetra-azacyclododecane, complexes with at least one metal ion equivalent of atomic number 57-83;
• 5-[bis(2-{[1-(sodium sulphonatobutyl)-3-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-4-carbonyl]amino}ethyl)amino]-4-{[1-(sodium sulphonato-butyl)-3-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-4-carbonyl]amino}pentane-carboxylic acid [N-(1H,1H,2H,2H,4H,4H,-3,6,9,12-tetraoxaperfluorohexadecyl)-N-(2-methoxyethyl)]amide, complexes with at least one metal ion equivalent of atomic number 57-83;
• and
• 6-N-(2,3-Dihydroxy-N-{[bis(2-{[1-(sodium sulphonatobutyl)-3-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-4-carbonyl]amino}ethyl)amino]ethyl}-terephthalyl)-2-N-(1-O-α-d-carbonylmethylmannopyranose)-L-lysine[N-methyl-(1H,1H,2H,2H,4H,4H,-3,6,9,12-tetraoxaperfluorohexadecyl)]amide, complexes with at least one metal ion equivalent of atomic number 57-83;
• and salts thereof.