Integrated bio-chip, method of fabricating the integrated bio-chip, and apparatus for detecting bio-material
AssigneeSamsung Electronics Co., Ltd.
InventorSeong-ho Cho
Life of this patent
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Abstract
An integrated bio-chip includes a substrate and one or more excitation light absorbing waveguides disposed in the substrate. The substrate includes one or more reaction regions on which samples are disposed. An end portion of each of the one or more excitation light absorbing waveguides is exposed from the substrate at an upper surface thereof, another end portion of each of the one or more excitation light absorbing waveguides is exposed from the substrate at a lower surface thereof, and the one or more reaction regions are disposed at a upper surface of the substrate. The one or more excitation light absorbing waveguides absorbs excitation light incident to the samples, and transmits fluorescent light emitted from the samples.
Claims31
An integrated bio-chip comprising:
- a substrate including one or more reaction regions on which samples are disposed;
- and
- one or more excitation light absorbing waveguides disposed in the substrate, wherein
- a first end portion of each of the one or more excitation light absorbing waveguides is exposed from the substrate at an upper surface thereof,
- a second end portion of each of the one or more excitation light absorbing waveguides is exposed from the substrate at a lower surface thereof,
- the one or more reaction regions are disposed at the upper surface of the substrate, and
- each of the one or more excitation light absorbing waveguides includes a color filter core which transmits fluorescent light emitted from the samples and absorbs excitation light which excites the samples,
- wherein each of the one or more excitation light absorbing waveguides is disposed in a through hole in the substrate that extends from the upper surface to the lower surface, and
- wherein the upper and lower surfaces define opposite major surface planes defining the substrate.
A method of fabricating an integrated bio-chip, the method comprising:
- forming one or more penetration holes in a substrate;
- forming one or more excitation light absorbing waveguides in the one or more penetration holes;
- wherein
- a first end portion of each of the one or more excitation light absorbing waveguides is exposed from the substrate at an upper surface thereof,
- a second end portion of each of the one or more excitation light absorbing waveguides is exposed from the substrate at a lower surface thereof, and
- each of the one or more excitation light absorbing waveguides includes a color filter core which transmits fluorescent light emitted from the samples and absorbs excitation light which excites the samples, and
- treating the upper surface of the substrate in which the one or more penetration holes are formed such that samples are attachable to reaction regions at which the one or more excitation light absorbing waveguides are formed,
- wherein the upper and lower surfaces define opposite major surface planes defining the substrate.
An apparatus for detecting bio-material using an integrated bio-chip comprising a substrate including one or more reaction regions on which samples are disposed and one or more excitation light absorbing waveguides disposed in the substrate, the apparatus comprising:
- an illuminating optical system which irradiates excitation light onto the integrated bio-chip;
- a stage detachably mounted to the integrated bio-chip;
- and
- a photodetector which detects fluorescent light emitted from the integrated bio-chip, wherein
- a first end portion of each of the one or more excitation light absorbing waveguides is exposed from the substrate at an upper surface thereof,
- a second end portion of each of the one or more excitation light absorbing waveguides is exposed from the substrate at a lower surface thereof,
- the one or more reaction regions are disposed at the upper surface of the substrate, and
- each of the one or more excitation light absorbing waveguides includes a color filter core which transmits fluorescent light emitted from the samples and absorbs excitation light which excites the samples,
- wherein each of the one or more excitation light absorbing waveguides is disposed in a through hole in the substrate that extends from the upper surface to the lower surface, and
- wherein the upper and lower surfaces define opposite major surface planes defining the substrate.
Dependencies are inferred from the claim text.