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US 8,262,948 B2Granted
Intraocular lenses with combinations of UV absorbers and blue light chromophores
AssigneeNovartis AG
InventorsWalter R. Laredo, Ali E. Akinay
Life of this patent
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Abstract
Disclosed are ophthalmic device materials having improved light transmission characteristics. The materials contain a combination of certain UV absorbers and blue-light absorbing chromophores.
Claims19
An ophthalmic device material comprising:
- a) a UV/Vis absorber of Formula A or Formula B shown below:
- wherein:
- R1═H, CH3, CH2CH3;
- or CH2OH;
- R2═C1-C4 alkyl or C1-C4 alkoxy;
- and
- R3═H, CH3, CH3O, F, Cl, Br, I, or CF3;
- wherein:
- X═C3-C4alkenyl, C3-C4 alkyl, CH2CH2CH2SCH2CH2 or CH2CH2CH2SCH2CH2CH2;
- Y=nothing if X═C3-C4 alkenyl, otherwise Y═—O—C(═O)—C(R1)═CH2, —O—C(═O)NHCH2CH2OC(═O)—C(R1)═CH2, or —O—C(═O)NHC(CH3)2(C6H4)C(CH3)═CH2;
- R1═H, CH3, CH2CH3, or CH2OH;
- R2═C1-C4 alkyl;
- and
- R3═H, CH3, CH3O, F, Cl, Br, I, or CF3;
- and
- b) a blue light chromophore, wherein the blue light chromophore is of Formula I or Formula II as shown below:
- wherein:
- R1═C(O)CH═CH2, C(O)C(CH3)═CH2, C(O)NHCH2CH2OC(O)C(CH3)═CH2, or C(O)NHC(CH3)2C6H4C(CH3)═CH2;
- R2═H, C1-C4 alkyl, OR C1-C4 alkoxy;
- R3═H, C1-C4 alkyl, F, Cl, Br, CN, NO2, COOR4;
- XOC(O)CH═CH2, XOC(O)C(CH3)═CH2, XOC(O)NHCH2CH2OC(O)C(CH3)═CH2, or XOC(O)NHC(CH3)2C6H4C(CH3)═CH2;
- R4═H or C1-C4 alkyl;
- and
- X═C1-C4 alkyl or C2-C4 alkenyl;
- wherein:
- X1, X2, and X3 independently=H, C1-C6 alkyl, C1-C6 alkoxy, phenoxy, or benzyloxy;
- Y═H, F, Cl, Br, I, or C1-C6 alkyl;
- W=direct bond or —O—C(═O)—NH—CH2—CH2—;
- and
- Z═H, CH3, C2H5, or CH2OH;
- and
- c) device forming polymeric material.
29 more elements
Dependencies are inferred from the claim text.