Biosensor coating composition and methods thereof
AssigneeAbbott Diabetes Care Inc.
InventorsNigel John Forrow, Shridhara Alva Karinka
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Abstract
The disclosure provides for reagent compositions for biosensors comprising release polymers, methods of making such biosensors and films of reagent compositions comprising release polymers. The reagent compositions comprise a release polymer and an effective analyte detecting amount of an enzyme an enzyme cofactor and a redox compound capable of acting in a biosensor as (i) a redox mediator associated with a working electrode (ii) a redox couple associated with a reference electrode or (iii) the redox mediator associated with the working electrode and the redox couple for the reference electrode.
Claims42
A biosensor comprising:
- at least one electrode;
- and
- a reagent composition associated with the at least one electrode, the reagent composition comprising:
- a polymer mixture comprising polyvinyl alcohol-polyethylene glycol graft copolymer and polyvinyl alcohol or a polymer mixture comprising polyvinyl acetate and polyvinylpyrrolidone and an effective analyte detecting amount of:
- an enzyme;
- an enzyme cofactor;
- and
- a redox compound capable of acting in a biosensor as
- (i) a redox mediator for a working electrode;
- (ii) a redox couple for a reference electrode;
- or
- (iii) a redox mediator for a working electrode and the redox couple for a reference electrode.
A biosensor film comprising
- a polymer mixture comprising polyvinyl alcohol-polyethylene glycol graft copolymer and polyvinyl alcohol or a polymer mixture comprising polyvinyl acetate and polyvinylpyrrolidone and an effective analyte detecting amount of:
- an enzyme;
- an enzyme cofactor;
- and
- a redox compound capable of acting in a biosensor as
- (i) a redox mediator for a working electrode;
- (ii) a redox couple for a reference electrode;
- or
- (iii) a redox mediator for a working electrode and the redox couple for a reference electrode.
A reagent composition comprising:
- a polymer mixture comprising polyvinyl alcohol-polyethylene glycol graft copolymer and polyvinyl alcohol or a polymer mixture comprising polyvinyl acetate and polyvinylpyrrolidone and an effective analyte detecting amount of:
- an enzyme;
- an enzyme cofactor;
- and
- a redox compound capable of acting in a biosensor as
- (i) a redox mediator associated with a working electrode;
- (ii) a redox couple associated with a reference electrode;
- or
- (iii) the redox mediator associated with the working electrode and the redox couple for the reference electrode.
Dependencies are inferred from the claim text.