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US 8,262,612 B1Granted
Apparatus to prevent reperfusion injury
AssigneeAdvanced Cardiovascular Systems, Inc.
InventorsDaniel L. Cox, Hongzhi Bai, Paul Consigny, Jessica G. Chiu
Life of this patent
Estimating the term…
Abstract
Embodiments of a method and apparatus to prevent reperfusion injury. In one embodiment, blood flow proximal to a lesion is occluded. An infusion catheter is advanced to a region distal to the lesion and an anti-reperfusion injury drug is delivered. The lesion may then be treated with a dilating device to reintroduce blood flow to the region distal to the lesion.
Claims25
An apparatus to prevent reperfusion injury within an arterial vessel, the apparatus comprising:
- an elongated catheter having a proximal region and a distal region, the distal region for advancement within an arterial vessel to a region proximal to a lesion;
- having only a single expandable member coupled to the elongated catheter near the distal region occludes blood flow proximal to the lesion causing blockage of blood flow to an ischemic region distal to the lesion;
- and
- an infusion catheter disposed within a first lumen formed within the elongated catheter, the infusion catheter slideable within the first lumen to extend a substantial length past the distal region of the elongated catheter, wherein the infusion catheter releases an anti-reperfusion drug through a distal tip opening in a distal terminal end of the infusion catheter, wherein, during release, an outer surface of the infusion catheter is exposed through the lesion, and the exposed outer surface has a diameter small enough to advance through the lesion without causing a large channel or reperfusion pathway to form through the lesion.
1 more element
An apparatus to prevent reperfusion injury within an arterial vessel, the apparatus comprising:
- an elongated catheter having a proximal region and a distal region, the distal region for advancement within an arterial vessel to a region proximal to a lesion;
- having only a single expandable member coupled to the elongated catheter near the distal region occludes blood flow proximal to the lesion causing blockage of blood flow to an ischemic region distal to the lesion;
- and
- an infusion catheter disposed within a first lumen formed within the elongated catheter, the infusion catheter slideable within the first lumen to extend a substantial length past the distal region of the elongated catheter, wherein the infusion catheter releases an anti-reperfusion drug through a distal tip opening in a distal terminal end of the infusions catheter, wherein, during release, an outer surface of the infusion catheter is exposed through the lesion, and the exposed outer surface has a tapered diameter that gradually reduces in size near the distal section for guiding through an inner diameter of the lesion.
1 more element
A system to prevent reperfusion injury within an arterial vessel, comprising:
- an elongated catheter having a proximal region and a distal region, the distal region for advancement within an arterial vessel to a region proximal to a lesion;
- having only a single expandable member coupled to the elongated catheter near the distal region occludes blood flow proximal to the lesion causing blockage of blood flow to an ischemic region distal to the lesion, wherein occluding comprises occluding blood flow proximal to the lesion, but not across the lesion or distal to the lesion;
- and
- an infusion catheter disposed within a first lumen formed within the elongated catheter, the infusion catheter slideable within the first lumen to extend a substantial length past the distal region of the elongated catheter, wherein the infusion catheter releases an anti-reperfusion drug downstream from the infusion catheter to treat the lesion.
1 more element
An apparatus using only a single expandable member to prevent reperfusion injury within an arterial vessel, the apparatus comprising:
- means for occluding a region proximal to a lesion within an arterial vessel using a single expandable member, wherein blood flow is only occluded proximal to the lesion, but is not occluded across the lesion, and is not occluded distal to the lesion;
- means for advancing an infusion catheter past the lesion and to a region distal to the lesion using a guidewire in a guidewire lumen;
- and
- means for releasing an anti-reperfusion drug to the region distal to the lesion using an infusion lumen.
1 more element
A system to prevent reperfusion injury within an arterial vessel, comprising:
- an elongated catheter having a proximal region and a distal region, the distal region for advancement within an arterial vessel to a region proximal to a lesion;
- an expandable member coupled to the elongated catheter near the distal region to occlude blood flow proximal to the lesion causing blockage of blood flow to an ischemic region distal to the lesion, wherein occluding comprises occluding blood flow proximal to the lesion, by using the expandable member to occlude the arterial vessel at a location proximal to the lesion;
- an infusion catheter disposed within a first lumen formed within the elongated catheter, the infusion catheter slideable within the first lumen to extend a substantial length past the distal region of the elongated catheter, wherein the infusion catheter is adapted to release an anti-reperfusion drug;
- a guidewire lumen to receive a guidewire to guide the infusion catheter, wherein the guidewire lumen is formed within the infusion catheter, wherein the guidewire extends externally along an outer wall of the elongated catheter along the proximal portion and enters the elongated catheter near the expandable member;
- and
- a dilatation catheter to reintroduce blood flow to the ischemic region distal to the lesion after release of the anti-reperfusion drug.
3 more elements
Dependencies are inferred from the claim text.