Needleless delivery systems

A needleless injector comprising

• a body at a proximal end,
• a first shaft extending distally from the body,
• a flexible shaft extending from the body to a distal end of the flexible shaft having a shaft terminus, wherein the flexible shaft is axially moveable along a longitudinal axis of the first shaft,
• an injection orifice at the distal end of the flexible shaft in fluid communication with a fluid chamber at the proximal end, the injection orifice being located on the flexible shaft at a proximal location relative to the shaft terminus, and the injection orifice being, positioned for fluid ejection in a lateral direction relative to a longitudinal axis of the flexible shaft,
• an extendable tissue tensioner located at the distal end of the flexible shaft proximal to the injection orifice,
• a pressure source in communication with the fluid chamber,
• wherein the needleless injector is capable of ejecting fluid as a pressurized stream from the injection orifice so the pressurized stream of fluid can pass through a surface of tissue of a urinary tract and become dispersed within tissue of a lower urinary tract as droplets.

A needleless injector comprising

• a body at a proximal end,
• a first shaft extending distally from the body,
• an injection shaft extending from the body to a distal end of the injection shaft, wherein the injection shaft is axially moveable along a longitudinal axis of the first shaft,
• an injection orifice at the distal end of the injection shaft in fluid communication with a fluid chamber at the proximal end, the injection orifice directed away from the longitudinal axis of the injection shaft to provide for lateral fluid ejection from the injection orifice,
• a pressure source in communication with the fluid chamber, and
• a tissue tensioner located at the distal end of the injection shaft proximal to the injection orifice, wherein:
• the injection orifice ejects fluid in a direction that includes a directional component away from a longitudinal axis of the injection shaft at the location of the ejection,
• the tissue tensioner is located at a length-wise position on the distal end of the injection shaft that is the same as a length-wise position of the injection orifice such that the device is capable of ejecting fluid from the injection orifice to penetrate tissue under tension by the tissue tensioner, and
• the needleless injector is capable of ejecting fluid from the injection orifice at a pressure to cause the fluid to pass through a tissue surface and become dispersed within tissue as droplets.