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US 8,262,555 B2Granted
Method for adaptive radiation treatment of breast tissue surrounding a cancer resection cavity of arbitrary shape
AssigneeXoft, Inc.
InventorsJames E. Jervis, Paul A. Lovoi
Life of this patent
Estimating the term…
Abstract
Radiation treatment methods for breast cancer following resection, both intraoperative and post operative, involve mapping preferably using an electronic x-ray source, and can include rotation of a direction source. By using a very rapid, near-instantaneous method of pathology of tissue margins following resection, the invention carries out intraoperative radiation treatment, preferably with the patient remaining anesthetized. Whether or not radiation is intraoperative, the invention preferably includes a mapping procedure using an electronic source that is progressed through the resection cavity while radiation dose is sensed at one or more points, to determine the shape of the resection cavity.
Claims28
A method for intraoperative radiation therapy treatment in a living patient, comprising:
- following excision of a tumor from a patient, while the patient remains under anesthesia, mapping the excision cavity by the steps of:
- (a) inserting an applicator into the excision cavity, the applicator including a series of guides,
- (b) before or after step (a), inserting one or more radiation sensors into peripheral ones of the guides and inserting an ionizing radiation source into a central one of the guides,
- (c) expanding the applicator to substantially fill the cavity, thereby placing the peripheral guides substantially at walls of the cavity adjacent to a volume to be treated with radiation,
- (d) moving the source and sensors through the guides and taking a reading with the sensor for each of a plurality of locations of the sensors along such movement, such locations being sufficient to substantially define the shape of the walls of the cavity,
- (e) from data determined in step (d), determining a three-dimensional model of the excision cavity,
- using a radiation prescription prepared by an attending physician, making a radiation treatment plan for a volume to be treated immediately surrounding the excision cavity based on the three-dimensional model of the cavity, while the patient remains under anesthesia and the applicator remains within the incision cavity, for irradiation of the volume to be treated by use of such ionizing radiation sources and the applicator, and
- executing the treatment plan by moving the ionizing radiation source through the central guide of the applicator with appropriate dwell times such that substantially the prescribed dose of radiation is received in all regions of the volume to be treated.
5 more elements
A method for three-dimensional mapping of a cavity in a human body, comprising:
- (a) inserting an applicator into the cavity, the applicator including a series of guides, including peripheral guides and a generally central guide,
- (b) expanding the applicator to substantially fill the cavity, thereby placing the peripheral guides substantially at walls of the cavity adjacent to a volume to be treated with radiation,
- (c) with one or more ionizing radiation sources in one or more of the guides and with a radiation sensor in one or more of the guides, such that one of a sensor and a source is in a generally central guide and the other is in at least one peripheral guide, moving the source and sensor through the guides and taking a reading with the sensor for each of a series of positions in the peripheral guide, along such movement, such locations being sufficient to substantially define the shape of the walls of the cavity,
- (d) from data determined in step (c), determining a three-dimensional model of the cavity.
1 more element
A method for radiation therapy treatment of a patient, comprising:
- (a) inserting an applicator into a cavity in the patient's body, the applicator including a series of guides, including peripheral guides and a generally central guide,
- (b) expanding the applicator to substantially fill the cavity, thereby placing peripheral guides substantially at walls of the cavity adjacent to a volume to be treated with radiation,
- (c) with one or more ionizing radiation sources in one or more of the guides and with a radiation sensor in one or more of the guides, such that one of a sensor and a source is in a generally central guide and the other is in at least one peripheral guide, moving the source and sensor through the guides and taking a reading with the sensor for each of a series of positions in the peripheral guide, along such movement, such locations being sufficient to substantially define the shape of the walls of the cavity,
- (d) from data determined in step {circle around (c)}, determining a three-dimensional model of the cavity,
- (e) making a radiation treatment plan for a volume to be treated immediately surrounding the cavity based on a radiation prescription and on the three-dimensional model of the cavity, for irradiation of the volume to be treated by use of such ionizing radiation sources and the applicator, and
- (f) executing the treatment plan by moving the ionizing radiation source through one or more guides of the applicator with appropriate dwell times such that substantially prescribed dose of radiation is received in all regions of the volume to be treated.
3 more elements
A method for treating with x-ray radiation a volume within a living patient while avoiding damage to sensitive areas and limiting radiation dose where needed, comprising:
- (a) placing a plurality of x-ray sensors adjacent to the volume to be treated, in an applicator,
- (b) placing a switchable x-ray source at a generally central location in the applicator so as to be generally surrounded by the sensors,
- (c) calibrating the plurality of x-ray sensors by switching the source on and off in turn, with the sensors clustered closely around the source, and determining the dose read at each of the x-ray sensors,
- (d) expanding the applicator within the volume to be treated, so as to spread the array of sensors outwardly as the applicator expands, thus spacing each sensor generally radially away from the source,
- (e) placing additional x-ray sensors outside the volume to be treated, so as to monitor x-ray radiation received at various sites outside the volume to be treated,
- (f) moving the x-ray source and the sensors through the volume to be treated, turning the x-ray source on and off in turn, and detecting the radiation from the source using the x-ray sensor at a series of different positions within the volume,
- (g) calculating the relative positions of all of the x-ray sensors and the x-ray source using information obtained from step (f),
- (h) making a treatment plan for the volume to be treated, based on x-ray radiation dose prescribed for various regions of the volume to be treated, and including a plan for moving the x-ray source and the sensors to different positions along the volume to be treated, with on/off switching of the source as needed, along the path of movement for the treatment plan,
- (i) executing the treatment plan by moving the x-ray source and sensors through the volume to be treated, in accordance with the treatment plan, and controlling x-ray delivery from the x-ray source in accordance with the treatment plan, including switching the source on and off as needed.
6 more elements
A method used in brachytherapy radiation treatment, to closely achieve a prescription radiation dose in a patient's tissue, comprising:
- positioning an applicator in a cavity or other location in the patient's tissue,
- moving an electronic x-ray source axially through a guide in the applicator and thus progressing the x-ray radiation through the tissue, either continuously or in steps, and
- applying a prescription radiation dose by varying voltage to the electronic x-ray source as the source advances through the applicator guide so as to vary the depth of penetration of x-ray radiation into tissue at different locations in the tissue.
A method used in brachytherapy radiation treatment, to closely achieve a prescription radiation dose in a patient's tissue, comprising:
- positioning an applicator in a cavity or other location in the patient's tissue,
- moving an electronic x-ray source axially through a guide in the applicator and thus progressing the x-ray radiation through the tissue, either continuously or in steps,
- applying a prescription radiation dose by varying voltage to the electronic x-ray source as the source advances through the applicator guide so as to vary the depth of penetration of x-ray radiation into tissue at different locations in the tissue, and
- controlling dose intensity by one of,
- varying current in the electronic x-ray source for different positions along the applicator guide, and
- varying dwell time of the electronic x-ray source for different positions along the applicator guide.
3 more elements
A method used in brachytherapy radiation treatment, to closely achieve a prescription radiation dose in a patient's tissue, comprising:
- positioning an applicator in a cavity or other location in the patient's tissue,
- making a radiation treatment plan for a volume to be treated immediately surrounding the cavity based on a radiation prescription for irradiation of the volume to be treated by use of an electronic x-ray source,
- executing the treatment plan by moving the electronic x-ray source axially through a guide in the applicator and thus progressing the x-ray radiation through the tissue with appropriate dwell times such that a prescribed dose of radiation is received in all regions of the volume to be treated, and
- controlling the prescription radiation dose by varying voltage to the electronic x-ray source as the source advances through the applicator guide so as to vary the depth of penetration of x-ray radiation into tissue at different locations in the tissue.
1 more element
Dependencies are inferred from the claim text.