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US 8,258,274 B2Granted
Vaccines containing canine parvovirus genetic variants
AssigneeThe Board of Regents for Oklahoma State University
InventorsSanjay Kapil, Emily Cooper
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Abstract
Canine parvovirus vaccines and diagnostics and methods for their use are provided.
Claims13
A canine immunogenic composition comprising parvovirus virions that have a type VP-2 protein, said parvovirus virions comprising a nucleic acid, said nucleic acid comprising the nucleotide sequence selected from the group consisting of:
- SEQ ID NO:
- 2;
- a sequence that is at least 95% homologous to SEQ ID NO:
- 2 wherein nucleotides 16-18 are CTG to encode Leu at position 431 of said VP-2 protein;
- SEQ ID NO:
- 4;
- and
- a sequence that is at least 95% homologous to SEQ ID NO:
- 4 wherein nucleotides 43-45are GCA to encode Ala at position 440 of said VP-2 protein.
6 more elements
A diagnostic kit for detecting parvovirus in domestic dogs and puppies, wild canids, wolves, wild dogs, domestic cats and kittens, wild cats, minks, red pandas, foxes, lions, tigers, animals in zoos or protected areas, and animals in research facilities, comprising
- hybridizable nucleic acids specific for detecting, in domestic dogs and puppies, wild canids, wolves, wild dogs, domestic cats and kittens, wild cats, minks, red pandas, foxes, lions, tigers, animals in zoos or protected areas, and animals in research facilities, a nucleic acid sequence selected from the group consisting of:
- a sequence that is at least 95% homologous to SEQ ID NO:
- 2 wherein nucleotides 16-18are CTG to encode Leu at position 431 of a VP-2 protein;
- and
- a sequence that is at least 95% homologous to SEQ ID NO:
- 4 wherein nucleotides 43-45are GCA to encode Ala at position 440 of a VP-2 protein.
3 more elements
Dependencies are inferred from the claim text.