Dual variable domain immunoglobulin and uses thereof
AssigneeAbbott Laboratories
InventorsChengbin Wu, Tariq Ghayur, Richard W. Dixon, Jochen G. Salfeld
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Abstract
The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
Claims47
A binding protein comprising first and second polypeptide chains, wherein said first polypeptide chain comprises VD1-(X1)n-VD2-C-(X2)n, wherein VD1 is a first heavy chain variable domain, VD2 is a second heavy chain variable domain, C is a constant domain, X1 is a linker with the proviso that it is not a constant domain, and X2 is an Fc region;
- and said second polypeptide chain comprises VD1-(X1)n-VD2-C-(X2)n, wherein VD1 is a first light chain variable domain, VD2 is a second light chain variable domain, C is a constant domain, X1 is a linker with the proviso that it is not a constant domain, and X2 does not comprise an Fc region;
- wherein n is 0 or 1;
- and wherein said two polypeptide chains of said binding protein form two functional binding sites.
A binding protein comprising first and second polypeptide chains, wherein:
- said first polypeptide chain comprises VD1-(X1)n-VD2-C-(X2)n, wherein VD1 is a first variable domain, VD2 is a second variable domain, C is a constant domain, X1 is a linker with the proviso that it is not a constant domain, X2 is an Fc region, and n is 0 or 1;
- and
- said second polypeptide chain comprises VD1-(X1)n-VD2-C, wherein VD1 is a first variable domain, VD2 is a second variable domain, C is a constant domain, and X1 is a linker with the proviso that it is not a constant domain, and n is 0 or 1;
- wherein said two polypeptide chains of said binding protein form two functional binding domains.
Dependencies are inferred from the claim text.