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US 8,258,199 B2Granted
Photoacid generators for the synthesis of oligo-DNA in a polymer matrix
AssigneeAffymetrix, Inc.
InventorsGlenn H. McGall, Andrea Cuppoletti
Life of this patent
Estimating the term…
Abstract
Compounds represented by the following structural formulas can be used as photoacid generators: Such compounds are useful, for example, in fabricating arrays of polymers.
Claims25
A composition comprising a compound represented by Structural Formula (III):
- or a salt thereof, wherein:
- R8 is a substituted sulfonyl, acetyl or benzoyl group;
- R9 is —H, —COOR, a substituted alkyl group or an alkenyl or aryl group;
- R10 is —NRR′, —COOR, an alkyl or alkenyl group or a substituted alkoxy or aryl group;
- and
- R and R′ are independently —H or an alkyl, alkenyl or aryl group, and a sensitizer.
3 more elements
A method of generating acid, comprising exposing to light of an appropriate wavelength a compound represented by Structural Formula (III):
- or a salt thereof, wherein:
- R8 is a substituted sulfonyl, acetyl or benzoyl group;
- R9 is —H, —COOR, a substituted alkyl group or an alkenyl or aryl group;
- R10 is —NRR′, —COOR, an alkyl or alkenyl group or a substituted alkoxy or aryl group;
- and
- R and R′ are independently —H or an alkyl, alkenyl or aryl group, wherein the wavelength is greater than 310 nm.
3 more elements
A method of manufacturing a polymer array, which comprises:
- (a) providing a substrate comprising a reactive group protected by an acid labile protective group;
- (b) coating the substrate with a film comprising a photoacid generator represented by Structural Formula (III):
- or a salt thereof, wherein:
- R8 is a substituted sulfonyl, acetyl or benzoyl group;
- R9 is —H, —COOR, a substituted alkyl group or an alkenyl or aryl group;
- R10 is —NRR′, —COOR, an alkyl or alkenyl group or a substituted alkoxy or aryl group;
- and
- R and R′ are independently —H or an alkyl, alkenyl or aryl group;
- and
- (c) activating the photoacid generator by application of light of a wavelength greater than 310 nm.
7 more elements
Dependencies are inferred from the claim text.